|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
|8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt||sc-202028||1 mg||$178.00||
|8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt||sc-202028A||5 mg||$745.00||
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt is a specific, potent and membrane permeant activator of the Epac cAMP receptor. The compound activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2'-O-Me-cAMP . Na Does not activate protein kinase A (PKA), and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP . Na is an extremely poor PKA activator. 8-CPT-2'-O-Me-cAMP . Na has a high lipophilicity which allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.
1. Enserink, J.M., et al. 2002. Nat. Cell Biol. 4: 901-906. PMID: 12402047
2. Kang, G., et al. 2003. J. Biol. Chem. 278: 8279-8285. PMID: 12496249
3. Rangarajan, S., et al. 2003. J. Cell Biol. 160: 487-493. PMID: 12578910
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