7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione CAS: 137346-42-0, MF: C25H26N4O4, MW: 446.5

7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (CAS 137346-42-0)

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CAS Number: 137346-42-0
Molecular Weight: 446.5
Molecular Formula: C25H26N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC50 value of 2.2 µM. It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/Diablo, caspase-3, and caspase-7. Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.


1. Ryan, B.M., et al. 2009. Cancer Treat Rev. 35: 553-562. PMID: 19559538
2. Shin, S., et al. 2001. Biochemistry. 40: 1117-1123. PMID: 11170436
3. Oikawa, T., et al. 2010. Biochem. Biophys. Res .Commun. 393: 253-258. PMID: 20117083

Physical State :
Solubility :
Soluble in ethanol (~0.5 mg/ml), DMF (~30 mg/ml), and DMSO (~30 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~599.6 °C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
interaction between survivin and the apoptosis-promoting protein Smac/Diablo: IC50 = 2.2 µM; KB : IC50 = 7.6 µM (human); L1210: IC50 = 9.6 µM (mouse); interaction of survivin with INCENP: IC50 = 20 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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