7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.
Soluble in water (Partly miscible), alkali hydroxide solutions, and DMSO (24 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Asked by: Kelly Ho
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Rated 5 out of
FengFeng, P. et al. (PubMed 26343602) reported that 7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice. -SCBT Publication Review
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