7,8-Dihydroxyflavone A TrkB agonist that inhibits glutamate-triggered apoptosis

7,8-Dihydroxyflavone (CAS 38183-03-8)

7,8-Dihydroxyflavone | CAS 38183-03-8 is rated 5.0 out of 5 by 1.
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Synonym: 7,8-DHF; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Application: A TrkB agonist that inhibits glutamate-triggered apoptosis
CAS Number: 38183-03-8
Molecular Weight: 254.24
Molecular Formula: C15H10O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.

Physical State :
Solid
Solubility :
Soluble in water (Partly miscible), alkali hydroxide solutions, and DMSO (24 mg/ml).
Storage :
Store at 4° C
Melting Point :
250-252 °C
Boiling Point :
494.4 °C at 760 mmHg
Density :
1.4 g/cm3
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
Tyrosine-protein kinase LCK: IC50 = 80 µg/ml (human); DNA gyrase subunit B: IC50 = 89.2 µg/ml (Escherichia coli K-12); Inhibitor of nuclear factor kappa B kinase beta subunit: IC50 = 9820 nM (human); Immunodeficiency virus 1: EC5050 = 10 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ3004000
PubChem CID :
1880
MDL Number :
MFCD00006836
EC Number :
253-812-4
SMILES :
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O

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Certificate of Analysis

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its purity?

Asked by: Kelly Ho
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2018-12-12
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Rated 5 out of 5 by from Feng Feng, P. et al. (PubMed 26343602) reported that 7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice. -SCBT Publication Review
Date published: 2015-01-03
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