7,8-dichloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a casein kinase 2 (CK2) inhibitor.CK2 is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis and its activity is increased in many tumors and proliferating tissues, which lends promise as an anti-cancer drug target. CAY10577 inhibits CK2 with an IC50 value of 0.8 µM.
1 Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 (2006).
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