5-Iodo-Indirubin-3'-monoxime is a highly potent, cell-permeable, and reversible inhibitor of GSK-3β. 5-Iodo-Indirubin-3'-monoxime also inhibits Cdk1 and Cdk5 activities by binding to the ATP-binding pocket of these enzymes.
1. Hoessel, R., et al., 1999. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature cell biology. 1(1): 60-7. PMID: 10559866
2. Leclerc, S., et al., 2001. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of biological chemistry. 276(1): 251-60. PMID: 11013232
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