5-Iodo-Indirubin-3prime-monoxime An inhibitor of GSK-3β, CDK-1, and CDK-5

5-Iodo-Indirubin-3′-monoxime

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Application: An inhibitor of GSK-3β, CDK-1, and CDK-5
Purity: ≥98%
Molecular Weight: 403.2
Molecular Formula: C16H10IN3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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5-Iodo-Indirubin-3'-monoxime is a highly potent, cell-permeable, and reversible inhibitor of GSK-3β. 5-Iodo-Indirubin-3'-monoxime also inhibits Cdk1 and Cdk5 activities by binding to the ATP-binding pocket of these enzymes.


References

1. Hoessel, R., et al., 1999. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature cell biology. 1(1): 60-7. PMID: 10559866
2. Leclerc, S., et al., 2001. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of biological chemistry. 276(1): 251-60. PMID: 11013232

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at -20° C
IC50 :
Cdk5: IC50 = 20 nM; Cdk1: IC50 = 25 nM; GSK-3β: IC50 = 9 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5472313
SMILES :
C1=CC=CC2=C1C(C(N2)=C3/C4=C(NC3=O)C=CC(=C4)I)=NO

Download SDS (MSDS)

Certificate of Analysis

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