5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0)

5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0) (CAS 26172-55-4)

5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI 2.0) | CAS 26172-55-4 is rated 5.0 out of 5 by 1.
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Synonym: Methylchloroisothiazolinone; 2-Methyl-5-chloro-3-isothiazolone; CMI
Application: An antimicrobial agent
CAS Number: 26172-55-4
Purity: Active Ingredient >14%
Molecular Weight: 149.60
Molecular Formula: C4H4ClNOS
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

5-Chloro-2-methyl-4-isothiazolin-3-one (CMI) is an antimicrobial agent. The ratio of CMI/MI is 2.5 – 4.0.

Formulation :
> 14% in water
Physical State :
Liquid
Storage :
Store at room temperature
Melting Point :
-21° C
Boiling Point :
100° C
Density :
1.25 g/mL(14% aq.)
Refractive Index :
1.378
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1760, Class 8, Packing group II
PubChem CID :
33344
MDL Number :
MFCD00792550
EC Number :
247-500-7
SMILES :
CN1C(=O)C=C(S1)Cl

Download SDS (MSDS)

Certificate of Analysis

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5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0)  Product Citations

See how others have used 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25809859  Yamamoto, Y. et al. 2015. J Appl Toxicol. 35: 1348-60.

PMID: # 24928155  Fujita, M. et al. J Pharmacol Toxicol Methods. 70: 94-105.

Citations 1 to 2 of 2 total

Hello, my question is, in the topicof the CoA it is written that only CMI is contain in the Solution. But at the End of the CoA, you see the Information that CMI and MI is contain. What the correct composition of this solution?

Asked by: MSBfR
Thank you very much for your question. sc-352647 (5-Chloro-2-methyl-4-isothiazolin-3-one, CAS 26172-55-4) is an aqueous solution containing a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-Methyl-4-isothiazolin-3-one (MI). It is soluble in methanol. For any further questions please contact our European Support Office in Germany directly. You can reach us by phone at: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com We are happy to assist you.
Answered by: Technical Support Europe
Date published: 2019-01-23

hello.., my question is straight: i like to use CMI (5-chloro-2 methyl-4 isothiazolin-3-one, in making a cosmetic based WATER GEL along with TEA and carbomer. please advice

Asked by: veer
Thank you for your question. We do not recommend or support the use of this chemical for therapeutic, diagnostic, or other non-research use such as in the manufacturing or testing of cosmetic products.
Answered by: Technical Support
Date published: 2017-05-15

What is the composition?

Asked by: chemsd02
Thank you for your question. sc-352647 (5-Chloro-2-methyl-4-isothiazolin-3-one, CAS 26172-55-4) is an aqueous solution containing a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-Methyl-4-isothiazolin-3-one (MI). It is soluble in methanol.
Answered by: Chemical Support 10
Date published: 2017-03-20

There is still precipitation in this product, is it still good?

Asked by: hawkeye11
Thank you for your question. In 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI), sc-352647, you may see small precipitates in the liquid which are the CMI and MI organic ingredients. These may sometimes not fully dissolve since the product is in aqueous solution and needs to stay at these concentrations. The product is still usable for its biological and chemical purposes.
Answered by: TechService7
Date published: 2017-01-20

Good morning :-) Is this diluted in water now? It seems to by looking at the SDS - but according to my lab mates, this was previously dissolved in methanol. I notice that it comes out of solution rather easily. Is vortexing sufficient before use? Thanks!

Asked by: Jenn
Thank you for your question. Yes, this is an aqueous solution, it is ideal if you vortex or sonicate it before use.
Answered by: Technical Support
Date published: 2016-09-23
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Rated 5 out of 5 by from Various publications cite 5 Various publications cite 5-Chloro-2-methyl-4-isothiazolin-3-one (CMI, Methylchloroisothiazolinone) as a preservative with antibacterial and anti-fungal effects. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi. -SCBT Publication Review
Date published: 2015-01-09
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