5-AIQ hydrochloride A PARP-1 inhibitor

5-AIQ hydrochloride (CAS 93117-07-8)

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Synonym: 5-Aminoisoquinolinone hydrochloride
Application: A PARP-1 inhibitor
CAS Number: 93117-07-8
Molecular Weight: 196.63
Molecular Formula: C9H8N2O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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5-AIQ hydrochloride is a selective PARP-1 inhibitor. Inhibition of PARP-1 prevents apoptosis via the PARP pathway.


References

Di Paola, R., et al., Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. Eur. J. Pharmacol. 492, 203-210, (2004); Cuzzocrea, S., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem. Pharmacol. 63, 293-304, (2002); McDonald, M.C., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br. J. Pharmacol. 130, 843-850, (2000);

Physical State :
Solid
Solubility :
Soluble in DMSO: >20 mg/mL and Water: >20 mg/mL
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16078941
MDL Number :
MFCD03452659
SMILES :
C1=CC2=C(C=CNC2=O)C(=C1)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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