5-AIQ hydrochloride is a selective PARP-1 inhibitor. Inhibition of PARP-1 prevents apoptosis via the PARP pathway.
Di Paola, R., et al., Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. Eur. J. Pharmacol. 492, 203-210, (2004); Cuzzocrea, S., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem. Pharmacol. 63, 293-304, (2002); McDonald, M.C., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br. J. Pharmacol. 130, 843-850, (2000);
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