4alpha-Phorbol 12,13-didecanoateAn activator of TRPV4

4α-Phorbol 12,13-didecanoate (CAS 27536-56-7)

4α-Phorbol 12,13-didecanoate | CAS 27536-56-7 is rated 5.0 out of 5 by 1.
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Synonym: 4αPDD
Application: An activator of TRPV4
CAS Number: 27536-56-7
Purity: 99%
Molecular Weight: 672.9
Molecular Formula: C40H64O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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4α-Phorbol 12,13-Didecanoate is a substituted diterpene alcohol that does not show tumor promoting activities like the structural analog phorbol 12,13-didecanoate. This compound has been used as a negative control for phorbol 12,13-didecanoate (sc-202286), and has been shown to activate TRPV4 receptors.


References

1. Trewyn, R.W. and Gatz, H.B. 1984. In Vitro. 20: 409-415. PMID: 6724621
2. Vriens, J., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 396-401. PMID: 14691263
3. Hatano, N., et al. 2009. Life Sci. 85: 808-814. PMID: 19879881

Appearance :
Film
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol, methanol, acetone, ether, and dimethyl formamide. Insoluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
TRPV4: EC5050 = 200-400 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
452544
MDL Number :
MFCD00036737
Beilstein Registry :
2514324
SMILES :
CCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)CCCCCCCCC)O)C

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Certificate of Analysis

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4alpha-Phorbol 12,13-didecanoate  Product Citations

See how others have used 4alpha-Phorbol 12,13-didecanoate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26673139  Galindo-Villegas, J. et al. 2016. J. Immunol. 196: 738-49.

PMID: # 26151856  Nothias-Scaglia, LF. et al. 2015. Fitoterapia. 105: 202-9.

PMID: # 9447980  Lu, Z et al. 1998. Mol. Cell. Biol. 18: 839-845.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Various publications cite the use of 4 Various publications cite the use of 4 -Phorbol 12,13-didecanoate as a negative control for phorbol 12,13-didecanoate, as it does not show the tumor promoting activities like its structural analog phorbol 12,13-didecanoate. 4 -Phorbol 12,13-didecanoate has also been shown to activate TRPV4 receptors. -SCBT Publication Review
Date published: 2015-04-03
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