4-Amino-1,8-naphthalimide A PARP-1 inhibitor

4-Amino-1,8-naphthalimide (CAS 1742-95-6)

4-Amino-1,8-naphthalimide | CAS 1742-95-6 is rated 5.0 out of 5 by 1.
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Synonym: 6-amino-1H-benz[de]isoquinoline-1
Application: A PARP-1 inhibitor
CAS Number: 1742-95-6
Purity: ≥96%
Molecular Weight: 212.2
Molecular Formula: C12H8N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Amino-1,8-naphthalimide is a small molecule inhibitor of PARP-1 (poly (ADP-ribose) polymerase-1), an enzyme responsible for mediating covalent attachment of residues to proteins. Inhibition of this enzyme can sensitize cells to the cytotoxicity of chemical agents, and can also decrease cell death related to reperfusion and ischemia-related oxygen free radicals by attenuating the rapid depletion of cellular NAD and ATP resulting from excessive activation of PARP.


References

1. Banasik, M., et al. 1992. J. Biol. Chem. 267: 1569-1575. PMID: 1530940
2. Thiemermann, C., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 679-683. PMID: 9012844

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at room temperature
Melting Point :
>360° C
Boiling Point :
~544.07° C at 760 mmHg (Predicted)
Density :
1.11 g/cm3 at 25° C (lit.)
Refractive Index :
n20D 1.77
IC50 :
Poly (ADP-ribose) polymerase-1 (PARP-1): IC50 = 0.18 µM
pK Values :
pKa: 9.53, pKb: 1.54
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE4081000
PubChem CID :
1720
MDL Number :
MFCD00006921
EC Number :
217-110-1
SMILES :
C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N

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Certificate of Analysis

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4-Amino-1,8-naphthalimide  Product Citations

See how others have used 4-Amino-1,8-naphthalimide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 17595514  Furukawa, A. et al. 2007. Cell. Physiol. Biochem. 20: 45-54.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Furukawa et al Furukawa et al. (PubMed ID 17595514) used 4-Amino-1,8-naphthalimide to inhibit PARP and conserve intracellular NAD concentrations. -SCBT Publication Review
Date published: 2015-02-20
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