3-MATIDAA potent mGluR-1 antagonist

3-MATIDA (CAS 518357-51-2)

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Application: A potent mGluR-1 antagonist
CAS Number: 518357-51-2
Purity: ≥99%
Molecular Weight: 215.23 (anhydrous)
Molecular Formula: C8H9NO4S•xH20
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-MATIDA is a potent metabotropic glutamate receptor 1(mGluR-1) antagonist (IC50 = 6.3 μM at rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA has been found to act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.


References

1. Moroni, F., et al. 2002. Neuropharmacology. 42: 741-751. PMID: 12015200
2. Cozzi, A., et al. 2002. Neuropharmacology. 43: 119-130. PMID: 12213266
3. Costantino, G., et al. 2004. Farmaco. 59: 93-99. PMID: 14871500

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM), and DMSO (50 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
AMPA: IC50 = 250 µM; mGlu4a: IC50 = > 300 µM; mGluR-1a: IC50 = 6.3 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
XM7572000
PubChem CID :
10398360
SMILES :
CC1=C(SC(=C1)C(=O)O)C(C(=O)O)N

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Certificate of Analysis

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