3-Deazaneplanocin, HCl salt An effective S-adenosylhomocysteine hydrolase inhibitor

3-Deazaneplanocin, HCl salt (CAS 120964-45-6)

3-Deazaneplanocin, HCl salt | CAS 102052-95-9 is rated 5.0 out of 5 by 1.
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Synonym: (1s,2r,5r)-5-(4-amino-1h-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Application: An effective S-adenosylhomocysteine hydrolase inhibitor
CAS Number: 120964-45-6
Purity: ≥97%
Molecular Weight: 298.72
Molecular Formula: C12H14N4O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-Deazaneplanocin, HCl salt is a carbocyclic analog of adenosine that acts as an effective SAHH (S-adenosylhomocysteine hydrolase) inhibitor. Research indicates that the compound may have antiviral properties and has been used in human promyelocytic leukemia cell line HL-60 studies. 3-Deazaneplanocin, HCl salt is an inhibitor of ENX-1.


References

1. Glazer, R.I., et al. 1986. Biochem. Biophys. Res. Commun. 135: 688-694. PMID: 3457563

Physical State :
Solid
Solubility :
Soluble in PBS & cell culture medium (1 mg/ml), and water (≥25 mg/ml).
pH :
L
Storage :
Store at 4° C
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
Vero: IC50 = 0.55 ug.mL-1 (chlorocebus aethiops)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
14563109
MDL Number :
MFCD18782644
SMILES :
C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N

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Certificate of Analysis

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3-Deazaneplanocin, HCl salt  Product Citations

See how others have used 3-Deazaneplanocin, HCl salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25549357  Ferraro, A. et al. 2014. PLoS ONE. 9: e115276.

PMID: # 23933322  Lee, JK. et al. 2013. Biochem. Biophys. Res. Commun. 438: 647-52.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from D'Angelo D'Angelo, V. et al. (PubMed 26268310) used 3-Deazaneplanocin, an EZH2 inhibitor, alone and in combination with Daunoblastine on cell viability, apoptotic death and cell cycle distribution of T cell established Jurkat cell line. The EZH2 inhibitor used in combination with Daunoblastine was synergistic in inducing growth inhibition and increasing the apoptosis in T-ALL Jurkat cells. -SCBT Publication Review
Date published: 2015-02-17
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