3-Deazaneplanocin, HCl salt is a carbocyclic analog of adenosine that acts as an effective SAHH (S-adenosylhomocysteine hydrolase) inhibitor. Research indicates that the compound may have antiviral properties and has been used in human promyelocytic leukemia cell line HL-60 studies. 3-Deazaneplanocin, HCl salt is an inhibitor of ENX-1.
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D'AngeloD'Angelo, V. et al. (PubMed 26268310) used 3-Deazaneplanocin, an EZH2 inhibitor, alone and in combination with Daunoblastine on cell viability, apoptotic death and cell cycle distribution of T cell established Jurkat cell line. The EZH2 inhibitor used in combination with Daunoblastine was synergistic in inducing growth inhibition and increasing the apoptosis in T-ALL Jurkat cells. -SCBT Publication Review
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