3-Deazaadenosine An inhibitor of leukocyte adhesion to TNF-treated endothelial cells

3-Deazaadenosine (CAS 6736-58-9)

3-Deazaadenosine | CAS 6736-58-9 is rated 5.0 out of 5 by 1.
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Synonym: 4-Amino-1-(Beta-D-ribofuranosyl)-1H-imidazo(4,5)-pyridine
Application: An inhibitor of leukocyte adhesion to TNF-treated endothelial cells
CAS Number: 6736-58-9
Purity: ≥98%
Molecular Weight: 266.25
Molecular Formula: C11H14N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-Deazaadenosine is a potent inhibitor of adenosine deaminase, an enzyme that catalyzes the removal of the amine group from adenosine. This compound exhibits antitumor activity against a range of leukemia cell lines. 3-Deazaadenosine is an inhibitor of SAHH.


References

1. Flexner, C.W., et al. Lancet 339, 438, (1992); 2. Jurgensen, C.H., et al. J. Immunol. 144, 653, (1990)

Appearance :
Crystalline powder
Physical State :
Solid
Storage :
Store at 4° C
Boiling Point :
665.69° C at 760 mmHg (Predicted)
Density :
1.91 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23190
MDL Number :
MFCD00153951
SMILES :
C1=CN=C(C2=C1N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Lee Lee, SY. et al. (PubMed 21311682) reported that induction of the intrinsic apoptotic pathway by 3-Deazaadenosine is mediated by BAX activation in HL-60 cells. -SCBT Publication Review
Date published: 2015-03-12
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