3-ATA A selective cyclin-dependent kinase 4 (CDK4) inhibitor

3-ATA (CAS 129821-08-5)

3-ATA | CAS 12982-10-85 is rated 5.0 out of 5 by 1.
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Synonym: 3-Amino-9-thio(10H)-acridone
Application: A selective cyclin-dependent kinase 4 (CDK4) inhibitor
CAS Number: 129821-08-5
Purity: ≥95%
Molecular Weight: 226.3
Molecular Formula: C13H10N2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-ATA is a specific inhibitor of CDK4(cyclin-dependent kinase 4). Studies show that 3-ATA reduces kainic acid induced apoptosis, and promotes growth arrest. Additionally, 3-ATA pre-treated cells are more likely to survive when exposed to kainic acid. Cerebellar granule neuron studies show that 3-ATA blocks doxorubicin nueronal cell death in a dose dependent manner.


References

1. Yuki, K. 1975. Kokubyo Gakkai Zasshi. 42: 444-472. PMID: 1063237
2. Verdaguer, E., et al. 2003. Neuroscience. 120: 599-603. PMID: 12895500
3. Otsuka, Y., et al. 2004. Neurosci. Lett. 365: 180-185. PMID: 15246544
4. Shin, J.S., et al. 2008. Int. J. Oncol. 32: 435-439. PMID: 18202766

Physical State :
Solid
Solubility :
Soluble in DMSO, and DMF.
Storage :
Store at room temperature
Melting Point :
181.11° C (Predicted)
Boiling Point :
439.10° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
IC50 :
CDK4: IC50 = 3.1 µM
pK Values :
pKb: 1.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3620127
MDL Number :
MFCD04037005
SMILES :
C1=CC=C2C(=C1)C(=S)C3=C(N2)C=C(C=C3)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shin et al Shin et al. (PubMed ID 18202766) found that 3-ATA inhibited CDK4 and induced growth arrest in SK-OV-3 cells. -SCBT Publication Review
Date published: 2015-06-22
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