3-ATA is a specific inhibitor of CDK4(cyclin-dependent kinase 4). Studies show that 3-ATA reduces kainic acid induced apoptosis, and promotes growth arrest. Additionally, 3-ATA pre-treated cells are more likely to survive when exposed to kainic acid. Cerebellar granule neuron studies show that 3-ATA blocks doxorubicin nueronal cell death in a dose dependent manner.
1. Yuki, K. 1975. Kokubyo Gakkai Zasshi. 42: 444-472. PMID: 1063237 2. Verdaguer, E., et al. 2003. Neuroscience. 120: 599-603. PMID: 12895500 3. Otsuka, Y., et al. 2004. Neurosci. Lett. 365: 180-185. PMID: 15246544 4. Shin, J.S., et al. 2008. Int. J. Oncol. 32: 435-439. PMID: 18202766
Soluble in DMSO, and DMF.
Store at room temperature
181.11° C (Predicted)
439.10° C at 760 mmHg (Predicted)
1.38 g/cm3 (Predicted)
n20D 1.78 (Predicted)
CDK4: IC50 = 3.1 µM
pKb: 1.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Shin et alShin et al. (PubMed ID 18202766) found that 3-ATA inhibited CDK4 and induced growth arrest in SK-OV-3 cells. -SCBT Publication Review
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