25-Hydroxyvitamin D2 is used in serum to measure the concentration of vitamin D produced by the skin. It is known that 25-Hydroxyvitamin D2 can be detected in human serum using high-performance liquid chromatography and ultraviolet detection. Vitamin D2, known as ergocalciferol, is a fat soluble secosteroid which regulates neuromuscular function, reduces inflammation and controls cell proliferation, differentiation and apoptosis. Furthermore, 25-Hydroxyvitamin D2 can be converted into calcitriol, which can act as a local cytokine.
1. Alvarez, J.C., et al. 2001. J. Chromatogr. B Biomed. Sci. Appl. 755: 129-135. PMID: 11393696
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Dabrowski et alDabrowski et al. (PubMed ID 26035242) found that 25-Hydroxycalciferol led to lower production of granulocytes and macrophages colony stimulating factor, interleukin 6, Tumor Necrosis Factor, and an increase in mRNA expression for Cathelicidin Antimicrobial Peptide (CAP) in pregnant women. -SCBT Publication Review
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