20alpha-Hydroxy Cholesterol An allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein

20α-Hydroxy Cholesterol (CAS 516-72-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 100ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 5-Cholestene-3β,20α-diol
Application: An allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein
CAS Number: 516-72-3
Molecular Weight: 402.65
Molecular Formula: C27H46O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

20α-Hydroxy Cholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that binds at a site distinct from the canonical cyclopamine binding site. 20α-Hydroxy Cholesterol activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). It induces Smo accumulation in primary cilia and also exhibits osteogenic activity and activates the liver X receptor (LXR).


References

1. Higley, N A., et al., 1984. The steatotic and cytotoxic effects of cholesterol oxides in cultured L cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 22(12): 983-92. PMID: 6542547
2. Kilsdonk, E P., et al., 1995. Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol. Journal of lipid research. 36(3): 505-16. PMID: 7775862
3. Cantwell, H., et al., 1998. The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. Cell biology and toxicology. 14(6): 401-9. PMID: 9879932

Physical State :
Solid
Solubility :
Soluble in Chloroform and Methanol
Storage :
Store at -20° C
Melting Point :
125-132° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
121935
SMILES :
CC(C)CCC[C@@](C)(O)C1CCC2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 85ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 31ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.