2-Deoxy-D-glucose An apoptosis and HXK inhibitor that lowers ATP levels in cancer cell lines

2-Deoxy-D-glucose (CAS 154-17-6)

2-Deoxy-D-glucose | CAS 154-17-6 is rated 5.0 out of 5 by 2.
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| See product citations (9)
Synonym: 2-Deoxy-D-arabinohexose; 2-Deoxyglucose
Application: An apoptosis and HXK inhibitor that lowers ATP levels in cancer cell lines
CAS Number: 154-17-6
Purity: ≥98%
Molecular Weight: 164.16
Molecular Formula: C6H12O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
2-Deoxy-D-glucose sc-202010 1 g $59.00
2-Deoxy-D-glucose sc-202010A 5 g $200.00

2-Deoxy-D-glucose is an apoptosis inhibitor that has been shown to be taken up by glial cells incubated with insulin. Studies indicate that this compound has the potential to suppress hypoxia in murine retinal tissue. Additionally, 2-Deoxy-D-glucose has been noted to be a glycolytic inhibitor via indirect inhibition of hexokinase (HXK) which results in endoplasmic reticulum stress. Other experiments suggest that this agent upregulates autophagy and lowers ATP levels in certain cancer cell lines. 2-Deoxy-D-glucose is an activator of AMPK and an inhibitor of GPI.


References

1. Clarke, D.W., et al. 1984. J. Biol. Chem. 259: 11672-11675. PMID: 6384211
2. Thakkar, N.S. and Potten, C.S. 1993. Cancer Res. 53: 2057-2060. PMID: 8481907
3. Xi, H., et al. 2010. Cancer Chemother Pharmacol. [Epub ahead of print]. PMID: 20593179
4. Pina, Y., et al. 2010. Invest Ophthalmol Vis Sci. [Epub ahead of print]. PMID: 20702830

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at 4° C
Melting Point :
146-147° C
Boiling Point :
~411.0° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +47°, 45h, c = 0.5 in water
pK Values :
pKa: 12.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MQ3325000
PubChem CID :
439268
Merck Index :
14: 2904
MDL Number :
MFCD00151328
EC Number :
205-823-0
Beilstein Registry :
1723331
SMILES :
C1[C@H]([C@@H]([C@H](OC1O)CO)O)O

Download SDS (MSDS)

Certificate of Analysis

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2-Deoxy-D-glucoseProduct Citations

See how others have used 2-Deoxy-D-glucose. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 19458084
Swietach, P. et al. 2009. The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. J. Biol. Chem.. 284: 20299-20310.

PMID: # 19570986
Martiáñez, T. et al. 2009. Generation of digital responses in stress sensors. J. Biol. Chem.. 284: 23902-23911.

PMID: # 19570986
Martiáñez, T. et al. 2009. Generation of digital responses in stress sensors. J. Biol. Chem.. 284: 23902-23911.

PMID: # 19491100
Nakajima, M. et al. 2009. Characterization of three beta-galactoside phosphorylases from Clostridium phytofermentans: discovery of d-galactosyl-beta1->4-l-rhamnose phosphorylase. J. Biol. Chem.. 284: 19220-19227.

PMID: # 18474591
Momcilovic, M. et al. 2008. Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J. Biol. Chem.. 283: 19521-19529.

PMID: # 18715873
Masia, R. et al. 2008. Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. J. Biol. Chem.. 283: 30322-30329.

PMID: # 18003619
Jung, YS. et al. 2008. Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death. J. Biol. Chem.. 283: 1018-1025.

PMID: # 18250167
Lin, YW. et al. 2008. Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism. J. Biol. Chem.. 283: 9146-9156.

PMID: # 12660321
Singh, R. et al. 2003. Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J. Am. Soc. Nephrol.. 14: 873-880.

Citations 1 to 9 of 9 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-202425, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17

The compound turns to a yellow solution instead of a normal white solution upon dissolving in water. Does the color affect its quality?

Asked by: two2igm05
Thank you for your question. This particular compound has a different color with each batch. The difference in color from lot-to-lot does not affect its performance, it is just an effect of the production process. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-16
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Rated 5 out of 5 by from No complaints about this product No complaints about this product. Used in cancer cell line.
Date published: 2015-09-04
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