2-Deoxy-D-glucose is an apoptosis inhibitor that has been shown to be taken up by glial cells incubated with insulin. Studies indicate that this compound has the potential to suppress hypoxia in murine retinal tissue. Additionally, 2-Deoxy-D-glucose has been noted to be a glycolytic inhibitor via indirect inhibition of hexokinase (HXK) which results in endoplasmic reticulum stress. Other experiments suggest that this agent upregulates autophagy and lowers ATP levels in certain cancer cell lines. 2-Deoxy-D-glucose is an activator of AMPK and an inhibitor of GPI.
1. Clarke, D.W., et al. 1984. J. Biol. Chem. 259: 11672-11675. PMID: 6384211 2. Thakkar, N.S. and Potten, C.S. 1993. Cancer Res. 53: 2057-2060. PMID: 8481907 3. Xi, H., et al. 2010. Cancer Chemother Pharmacol. [Epub ahead of print]. PMID: 20593179 4. Pina, Y., et al. 2010. Invest Ophthalmol Vis Sci. [Epub ahead of print]. PMID: 20702830
Soluble in water.
Store at 4° C
~411.0° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.58 (Predicted)
α20/D +47°, 45h, c = 0.5 in water
pKa: 12.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
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See how others have used 2-Deoxy-D-glucose. Click on the entry to view the PubMed entry
Thank you for your question. The compound, sc-202425, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing firstname.lastname@example.org, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
The compound turns to a yellow solution instead of a normal white solution upon dissolving in water. Does the color affect its quality?
Asked by: two2igm05
Thank you for your question.
This particular compound has a different color with each batch. The difference in color from lot-to-lot does not affect its performance, it is just an effect of the production process.
Please contact Technical Service if you have further questions concerning this product.
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