2,5-Di-tert-butylhydroquinone (DBHQ) An inducer of Ca2+

2,5-Di-tert-butylhydroquinone (DBHQ) (CAS 88-58-4)

Synonym: DTBHQ; 2,5-Di-tert-butyl-1,4-hydroquinone
Application: An inducer of Ca2+
CAS Number: 88-58-4
Purity: 99%
Molecular Weight: 222.3
Molecular Formula: C14H22O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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2,5-Di-tert-butylhydroquinone (DBHQ) has been shown to be a selective and potent inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which is shown to cause induction of Ca2+ release from agonist-insensitive and agonist-sensitive intracellular stores. In isolated rat hepatocyte studies, DBHQ was reported to induce a rapid increase in cytosolic Ca2+ concentration without loss of other microsomal enzyme activity, altering membrane permeability, or modification of microsomal protein thiols.


References

1. Moore, G.A., et al. 1987. FEBS Lett. 224: 331-336. PMID: 2961610
2. Muallem, S., et al. 1991. Biochem. J. 279: 367-375. PMID: 1659378
3. Mason, M.J., et al. 1991. J. Biol. Chem. 266: 20856-20862. PMID: 1834651
4. Schilling, W.P., et al. 1992. Biochem. J. 284: 521-530. PMID: 1318033
5. Khan, Y.M., et al. 1995. Biochemistry. 34: 14385-14393. PMID: 7578042

Physical State :
Solid
Solubility :
Soluble in acetone, benzene, aqueous alkali, DMSO (25 mg/ml warm), and 100% ethanol.
Storage :
Store at room temperature
Melting Point :
210-212° C
Boiling Point :
321° C
Density :
1.07 g/cm3
Refractive Index :
n20D 1.52
IC50 :
Induces a rapid increase in cytosolic Ca2+ concentration: EC5050 = 1-2 µM (isolated rat hepatocytes)
pK Values :
pKa: 11.89
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MX5160000
PubChem CID :
2374
MDL Number :
MFCD00008825
EC Number :
201-841-8
Beilstein Registry :
2049542
SMILES :
CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O

Download SDS (MSDS)

Certificate of Analysis

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