2,4-Diacetylphloroglucinol An antifungal secondary metabolite

2,4-Diacetylphloroglucinol (CAS 2161-86-6)

2,4-Diacetylphloroglucinol | CAS 2161-86-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_20, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_206518, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 60ms
  • REVIEWS, PRODUCT
Synonym: 1,1-(2,4,6-Trihydroxy-1,3-phenylene)bis-ethanone; 1,3-Diacetyl-2,4,6-trihydroxybenzene; 5-Acetyl-2,4,6-trihydroxyacetophenone; DAPG
Application: An antifungal secondary metabolite
CAS Number: 2161-86-6
Molecular Weight: 210.18
Molecular Formula: C10H10O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

2,4-Diacetylphloroglucinol is a secondary metabolite of the P. Fluorescens strain CHAo which inhibits bacteria, fungi, and plants and suppresses pathogens. 2,4-Diacetylphlo roglucinol also displays antiviral activity against DNA and RNA viruses with envelopes.


References

Journal of Antibiotics, 31,11, 1201 (1978), Tada, M., et al.: Agric. Biol. Chem., 54, 3061 (1990), Tada, M., et al.: J. Med. Chem., 35, 1209 (1992), Molecular Plant-Microbe Interactions, 5, 1 (1992)

Physical State :
Solid
Solubility :
Soluble in water, ethanol, and methanol.
Storage :
Store at -20° C
Melting Point :
166-167° C
Boiling Point :
~374.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Streptokinase A: EC5050 = 2.64 µM (streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 3.90 µM; LLC-PK1: IC50 = 52.34 µM (pig); Vero: IC50 = 57.09 µM (monkey); Leishmania donovani: IC50 = 128.46 µM
pK Values :
pKa: 7.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
SY1100000
PubChem CID :
16547
MDL Number :
MFCD00100483
Beilstein Registry :
1881572
SMILES :
CC(=O)C1=C(C(=C(C=C1O)O)C(=O)C)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

2,4-Diacetylphloroglucinol  Product Citations

See how others have used 2,4-Diacetylphloroglucinol. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 28202725  Liu, X. et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: 2200-2205.

PMID: # 25422271  Nielsen, AA. et al. 2014. Mol. Syst. Biol. 10: 763.

PMID: # 24689296  Ahmed, MH. et al. 2014. Nat Prod Commun. 9: 221-4.

PMID: # 25360681  Stanton, BC. et al. 2014. ACS Synth Biol. 3: 880-91.

PMID: # 22361469  Zhou, T. et al. 2012. Microbiol. Res. 167: 388-94.

Citations 1 to 5 of 5 total

What is the expected purity of this product (sc-206518). I am required to list it in the methods section of a forthcoming publication.

Asked by: ameyer
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-12
  • y_2019, m_7, d_20, h_16CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_206518, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 65ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Veena Veena, VK. Et al. (PubMed 26283170) reported for the first time the anti-proliferative, proapoptotic, antimetastatic and anti-inflammatory activities of DAPG, an anti-fungal secondary metabolite, in various cancer cells and inflammation-induced immune cells. -SCBT Publication Review
Date published: 2015-06-26
  • y_2019, m_7, d_20, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_206518, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 38ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.