12(S)-HPETEA fatty acid and an activator of human blood leukocyte 5-LO

12(S)-HPETE (CAS 71774-10-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 104ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 12S- hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Application: A fatty acid and an activator of human blood leukocyte 5-LO
CAS Number: 71774-10-2
Purity: ≥98%
Molecular Weight: 336.5
Molecular Formula: C20H32O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1.


References

1. Hammarström, S., et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 3691-3695. PMID: 410024
2. Maclouf, J., et al 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 6042-6046. PMID: 6821131
3. Pace-Asciak, C.R., et al. 1983. J. Biol. Chem. 258: 6835-6840. PMID: 6406490
4. Piomelli, D., et al. 1987. Nature. 328: 38-43. PMID: 2439918
5. Piomelli, D., et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 8550-8554. PMID: 2554319
6. Brüne, B. and Ullrich, V. 1991. Mol. Pharmacol. 39: 671-678. PMID: 1674588
7. Kishimoto, K., et al. 1996. Biochim. Biophys. Acta. 1300: 56-62. PMID: 8608163
8. Rao, G.N., et al. 1996. J. Biol. Chem. 271: 27760-27764. PMID: 8910370
9. Nishiyama, M., et al. 1998. Eur. J. Pharmacol. 341: 57-63. PMID: 9489856

Formulation :
50 µg/ml in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (0.8 mg/ml at 25.0° C), DMSO, DMF, ethanol, pH 7.2 PBS (0.8 mg/ml), 0.1M Na2CO3 (2 mg/ml), and dimethyl formamide.
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.51
IC50 :
Ca2+-calmodulin-dependent protein kinase II: IC50 = 0.7 µM
Ki Data :
Endogenous TRPV1: Ki= 0.35 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
656507
SMILES :
CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 108ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 42ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.