1-EBIO A potassium channel modulator of epithelial KCa channels

1-EBIO (CAS 10045-45-1)

1-EBIO | CAS 10045-45-1 is rated 5.0 out of 5 by 1.
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Synonym: 1-ethyl-1,3-dihydro-2h-benzimidazol-2-one
Application: A potassium channel modulator of epithelial KCa channels
CAS Number: 10045-45-1
Purity: >99%
Molecular Weight: 162.19
Molecular Formula: C9H10N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-EBIO is the first activator of epithelial KCa channels identified. 1-EBIO stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic valve endothelial cells. 1-EBIO is an activator of CFTR, SK and Ik1.


References

1. Devor, D.C., et al. 1996. Am. J. Physiol. 271: L775-L784. PMID: 8944721
2. Adeagbo, A.S. 1999. Eur. J. Pharmacol. 379: 151-159. PMID: 10497901
3. Kusama, N., et al. 2005. Br. J. Pharmacol. 146: 487-497. PMID: 16056232

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), DMSO (100 mM), and tris buffer solution (33 mM).
Storage :
Store at room temperature
Melting Point :
121-123° C
Boiling Point :
327.75° C (Predicted)
Density :
1.16 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Ki Data :
Single ptotein: Ki= >50 µM (rat)
pK Values :
pKa: 12.29 (Predicted), pKb: 0.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE2566500
PubChem CID :
82320
MDL Number :
MFCD00005715
EC Number :
233-148-1
SMILES :
CCN1C2=CC=CC=C2NC1=O

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Certificate of Analysis

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1-EBIO  Product Citations

See how others have used 1-EBIO. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25962662  Kobuchi, S. et al. 2015. Eur. J. Pharmacol. 762: 26-34.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Kusama et al Kusama et al. (PubMed ID 16056232) found that 1-EBIO stimulated hyperpolarization in endothelial cells via KCa channel activation. -SCBT Publication Review
Date published: 2015-05-25
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