1-Chloro-2,4-dinitrobenzene is a substrate of GST. It has been used as alkylating agent to evaluate the depletion of intracellular erythrocyte glutathione (GSH). 1-Chloro-2,4-dinitrobenzene on incubation with erythrocyte undergoes conjugation with erythrocyte glutathione (GSH) to form 2,4-dinitrophenyl-S-glutathione. It is an irreversible inhibitor of human thioredoxin reductase. Additionally, it is a skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with the product has been used as a measure of cellular immunity. Also, 1-chloro-2,4-dinitrobenzene is used as a reagent for the detection and determination of pyridine compounds.
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