1,2-Dipalmitoyl-L-alpha-phosphatidyl-D-myo-inositol 4,5-bisphosphate A critical component in signaling pathways

1,2-Dipalmitoyl-L-α-phosphatidyl-D-myo-inositol 4,5-bisphosphate (CAS 120595-88-2)

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Application: A critical component in signaling pathways
CAS Number: 120595-88-2
Purity: ≥98%
Molecular Weight: 971.0
Molecular Formula: C41H81O19P3
* Refer to Certificate of Analysis for lot specific data (including water content).
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1,2-Dipalmitoyl-L-α-phosphatidyl-D-myo-inositol 4,5-bisphosphate is a 4,5-bisphosphate group on the inositol ring is critical for binding specifically to PH domains that are commonly present in signalling proteins. Also found in cytoskeleton.


References

Structure of the binding site for inositol phosphate in a PH domain: M. Hyvonen, et al.; EMBO J. 14, 4676 (1995) Abstract Inositolpolyphosphates and their binding proteins--a short review: B. Huisamen & A. Lochner; Mol. Cell. Biochem. 157, 229 (1996) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997) Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking: T.F. Martin; Annu. Rev. Cell. Dev. Biol. 14, 231 (1998), (Review) The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate: A. Toker; Curr. Opin. Cell Biol. 10, 254 (1998) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate: R. Rohatgi, et al.; J. Cell Biol. 150, 1299 (2000)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, DMSO, methanol, ethanol, and chloroform.
Storage :
Store at -20° C
Boiling Point :
995.95° C at 760 mmHg (Predicted)
Density :
1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
643962
MDL Number :
MFCD01861927
SMILES :
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O[C@@H]1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(=O)(O)O)OP(=O)(O)O)O)O)OC(=O)CCCCCCCCCCCCCCC

Download SDS (MSDS)

Certificate of Analysis

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1,2-Dipalmitoyl-L-alpha-phosphatidyl-D-myo-inositol 4,5-bisphosphate  Product Citations

See how others have used 1,2-Dipalmitoyl-L-alpha-phosphatidyl-D-myo-inositol 4,5-bisphosphate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28697598  Zheng, K. et al. 2017. J. Agric. Food Chem. 65: 6625-6637.

Citations 1 to 1 of 1 total
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