1,2-bis(Heptanoylthio)glycerophosphocholine A lipid tool for assay of PLA2 activity

1,2-bis(Heptanoylthio)glycerophosphocholine (CAS 89019-63-6)

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Application: A lipid tool for assay of PLA2 activity
CAS Number: 89019-63-6
Purity: ≥95%
Molecular Weight: 513.7
Molecular Formula: C22H44NO6PS2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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1,2-bis(Heptanoylthio)glycerophosphocholine is a synthetic thiol phosphoglyceride lipid derived from D-mannitol which functions as a substrate for PLA2 (phospholipase A2). Hydrolysis of 1,2-bis(Heptanoylthio)glycerophosphocholine by PLA2 produces free thiols, which may be derivitized with dithionitrobenzoic acid to form the chromophore for a spectrophotometric assay of intracellular and membrane-bound PLA2 activity. Release of Arachidonic Acid (sc-200770) from membrane phospholipids mediated by PLA2 is thought to regulate eicosanoid production and marked PLA2 activity is observed in correlation with inflammation states. Inhibitors of PLA2 activity, presenting potential intervention upon the inflammatory role of PLA2, have been identified using this assay design. 1,2-bis(Heptanoylthio)glycerophosphocholine is a substrate of PLA1.


References

1. Hendrickson, H.S., et al. 1983. J. Lipid Res. 24: 1532-1537. PMID: 6655369
2. Reynolds, L.J., et al. 1992. Anal. Biochem. 204: 190-197. PMID: 1514686
3. Petrovic, N., et al. 2001. J. Lipid Res. 42: 1706-1713. PMID: 11590228

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in methanol (5 mg/ml), and Tris buffer pH 8.5 (5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
78° C
Fluoresence :
λex 360 nm, λem 460 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCCCCCC(=O)SC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)SC(=O)CCCCCC

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Certificate of Analysis

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