1,1-Dimethylbiguanide, Hydrochloride 1,1-Dimethylbiguanide, Hydrochloride is an antihyperglycemic biguanide that induces fatty acid oxidation and stimulates AMPK leading to the reduction in acetyl-CoA carboxylase activity.

1,1-Dimethylbiguanide, Hydrochloride  (CAS 1115-70-4)

1,1-Dimethylbiguanide, Hydrochloride is rated 5.0 out of 5 by 1.
  • 2016-10-24T11:30CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202000, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 72ms
| See 4 Citations
Synonym: Metformin hydrochloride
Application: A antihyperglycemic biguanide which stimulates AMPK
CAS Number: 1115-70-4
Purity: ≥99%
Molecular Weight: 165.62
Molecular Formula: C4H11N5•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

1,1-Dimethylbiguanide, Hydrochloride sc-202000 1 g $20.00
1,1-Dimethylbiguanide, Hydrochloride sc-202000A 5 g $31.00

1,1-Dimethylbiguanide, Hydrochloride (Metformin) is a biguanide antihyperglycemic agent. Through glucose clamp investigation in rats 1,1-Dimethylbiguanide, Hydrochloride has been shown to lower blood glucose levels through improved glucose tolerance without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. The biguanide reduces the diabetic complications on the cardiovascular system and increases insulin sensitivity. The compound has been shown not to change the synthesis of either GLUT4 or GLUT1 but does stimulate the transport of GLUT1 to the plasma membrane as seen in skeletal muscles. The compound has also been observed to improve peripheral arterials through selective reduction of PAI-1 (plasminogen activator inhibitor). In Xenopus oocytes the compound has been documented to act by increasing intercellular calcium concentration in addition to elevating receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate. 1,1-Dimethylbiguanide, Hydrochloride has demonstrated the ability to induce fatty acid oxidation and to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase activity. In brown adipocytes 1,1-Dimethylbiguanide, Hydrochloride has been observed to inhibit leptin secretion via a mitogen-activated protein kinase signalling pathway.


1. Vague, P.,et al. 1987. Thromb. Haemost. 57: 326-328. PMID: 3310318
2. Rossetti, L., et al. 1990. Metab. Clin. Exp. 39: 425-435. PMID: 2157941
3. Stith, B.J., et al. 1996. Endocrinology. 137: 2990-2999. PMID: 8770923
4. Lin, H.Z., et al. 2000. Nat. Med. 6: 998-1003. PMID: 10973319
5. Zhou, G., et al. 2001. J. Clin. Invest. 108: 1167-1174. PMID: 11602624
6. Cleasby, M.E., et al. 2004. Diabetes. 53: 3258-3266. PMID: 15561958
7. Klein, J., et al. 2004. J. Endocrinol. 183: 299-307. PMID: 15531718
8. Mohiuddin, M., et al. 2009. Pak. J. Biol. Sci. 12: 734-737. PMID: 19634481

Appearance :
Physical State :
Solubility :
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
Storage :
Store at 4° C
Melting Point :
223-226° C (lit.)
Boiling Point :
224.1° C at 760 mmHg
IC50 :
Streptococcus sp. 'group A': EC5050 = 4.08 µM; Streptokinase A: EC5050 = 5.65 µM (Streptococcus pyogenes serotype M1)
pK Values :
pKb: 12.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 5938
MDL Number :
EC Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

1,1-Dimethylbiguanide, Hydrochloride Product Citations

See how others have used 1,1-Dimethylbiguanide, Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26771051
Kinsky, OR. et al. 2016. Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans. Chemical research in toxicology.

PMID: # 11994296
Fryer, LG. et al. 2002. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem.. 277: 25226-25232.

PMID: # 11602624
Zhou, G. et al. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest.. 108: 1167-1174.

PMID: # 9428832
Garber, AJ. et al. 1997. Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial. Am. J. Med.. 103: 491-497.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 54ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Fryer et al Fryer et al. (PubMed ID 11994296) used 1,1-Dimethylbiguanide, Hydrochloride (metformin hydrochloride) to activate AMPK in hepatocytes without having to increase AMP:ATP ratios. -SCBT Publication Review
Date published: 2015-03-09
  • 2016-10-24T11:30CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202000, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.