Troglitazone A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent

Troglitazone (CAS 97322-87-7)

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Solicitud: A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent
Número de CAS: 97322-87-7
Pureza: ≥98%
Peso Molecular: 441.5
Fórmula Molecular: C24H27NO5S
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Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells.


References

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Estado de Materia :
Solid
Solubilidad :
Soluble in ethanol (>25 mg/ml) at 50° C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25° C.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
312.54° C (Predicted)
Punto de ebullición :
~657.0° C at 760 mmHg (Predicted)
Densidad :
~1.3 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.61 (Predicted)
IC50 :
Stimulatin PPARγg glucose transport: EC5050 = 1 µM (adipocytes); PPARγ: EC5050 = 780 nM (murine); PPARγ: EC5050 = 555 nM (human); Induces cell cycle arrest and apoptosis: EC5050 = 10 µM (cancer cell lines); Monoamine oxidase B: IC50 = 2.07 µM (human)
Datos Ki :
Peroxisome proliferator-activated receptor gamma: Ki= 3.8 µM (human)
Valores de pK :
pKa: 6.35 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
2
RTECS :
XJ5813130
PubChem CID :
5591
Indice de Merck :
14: 9769
Número MDL :
MFCD00878416
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

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Troglitazone  Menciones del Producto

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Citaciones 1 a 4 de un total de 4

PMID: # 26313919  Myneni, VD. et al. 2015. Cell death & disease. 6: e1868.

PMID: # 24910239  Penner, N. et al. 2014. Drug Metab Lett. 8: 36-42.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

PMID: # 22981620  Kim, JA. et al. 2012. Toxicology letters. 214: 175-81.

Citaciones 1 a 4 de un total de 4
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