Stauprimide An indolocarbazole promoter of embryonic stem cell differentiation

Stauprimide (CAS 154589-96-5)

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Sinónimo: N-Benzoyl-7-oxostaurosporine
Solicitud: An indolocarbazole promoter of embryonic stem cell differentiation
Número de CAS: 154589-96-5
Pureza: >95%
Peso Molecular: 584.6
Fórmula Molecular: C35H28N4O5
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Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide.


References

1. Zhu, Shoutian., et al., 2009. A small molecule primes embryonic stem cells for differentiation. Cell stem cell. 4(5): 416-26. PMID: 19427291

Estado de Materia :
Solid
Forma Derivada :
Streptomyces
Solubilidad :
Soluble in ethanol (slightly), methanol, DMSO (100 mg/ml), DMF, and water (limited).
ALMACENAMIENTO :
Store at -20° C
Densidad :
~1.5 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.78 (Predicted)
IC50 :
Increases the efficiency of directed differentiation: EC5050 = 0.3 µM (Sox17+ /Sox7- cells)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
46245328
Número MDL :
MFCD14635443
SMILES :
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

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