Purvalanol A A selective inhibitor of cyclin-dependent kinases

Purvalanol A (CAS 212844-53-6)

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Sinónimo: 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
Solicitud: A selective inhibitor of cyclin-dependent kinases
Número de CAS: 212844-53-6
Pureza: ≥99%
Peso Molecular: 388.89
Fórmula Molecular: C19H25ClN6O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (Cdks). IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Purvalanol A reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Estado de Materia :
Solid
Solubilidad :
Soluble in methylene chloride (50 mg/ml), DMSO (100 mg/ml), ethanol (50 mM), methanol, and dichloromethane.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
243.74° C (Predicted)
Punto de ebullición :
590.47° C at 760 mmHg (Predicted)
Densidad :
1.34 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.65 (Predicted)
IC50 :
cdc2/cyclin B: IC50 = 4 nM; Cdc2 p34: IC50 = 4 nM (human); Cdk2: IC50 = 4 nM (human); cdk2/cyclin E: IC50 = 35 nM; cdk2/cyclin A: IC50 = 70 nM
Valores de pK :
pKb: 4.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Alemania :
3
PubChem CID :
456214
Número MDL :
MFCD02179211
Registro Beilstein :
8645511
SMILES :
CC(C)[C@H](CO)NC1=NC2=C(C(=N1)NC3=CC(=CC=C3)Cl)N=CN2C(C)C

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CERTIFICADO DE ANÁLISIS

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Purvalanol A  Menciones del Producto

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Citaciones 1 a 1 de un total de 1

PMID: # 26549230  Mori, Y. et al. 2015. Biochemical and biophysical research communications. 468: 642-6.

Citaciones 1 a 1 de un total de 1
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