Purmorphamine An activator of the hedgehog (Hh) signaling pathway

Purmorphamine (CAS 483367-10-8)

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Sinónimo: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Solicitud: An activator of the hedgehog (Hh) signaling pathway
Número de CAS: 483367-10-8
Pureza: ≥98%
Peso Molecular: 520.62
Fórmula Molecular: C31H32N6O2
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Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.


References

1. Cooper, M K., et al., 1998. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (New York, N.Y.). 280(5369): 1603-7. PMID: 9616123
2. Wu, Xu., et al., 2004. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chemistry & biology. 11(9): 1229-38. PMID: 15380183
3. Beachy, Philip A., et al., 2004. Tissue repair and stem cell renewal in carcinogenesis. Nature. 432(7015): 324-31. PMID: 15549094
4. Beloti, Márcio M., et al., 2005. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell biology international. 29(7): 537-41. PMID: 15979909
5. Sinha, Surajit., et al., 2006. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature chemical biology. 2(1): 29-30. PMID: 16408088

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml), and chloroform.
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
790.31° C at 760 mmHg (Predicted)
Densidad :
1.35 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.71 (Predicted)
IC50 :
Sonic hedgehog protein: EC5050 = 1 µM (mouse); Smo: IC50 = 1.5 µM (human)
Valores de pK :
pKb: 5.45 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
5284329
Número MDL :
MFCD09037557
SMILES :
C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76

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Purmorphamine  Menciones del Producto

Ver como otros han utilizado Purmorphamine. Haga click en la entrada de PubMed .

Citaciones 1 a 6 de un total de 6

PMID: # 26492376  Di Salvio, M. et al. 2015. Cell Death Dis. 6: e1943.

PMID: # 26387793  Li, AS. et al. 2015. Mol. Reprod. Dev. 82: 1015-36.

PMID: # 25873861  Watmuff, B. et al. 2015. Front Cell Neurosci. 9: 104.

PMID: # 24593882  El Maarouf, A. et al. 2015. Cell Transplant. 24: 797-809.

PMID: # 26025403  Salehi, M. et al. 2015. Cell. Mol. Biol. (Noisy-le-grand). 61: 56-9.

PMID: # 20193674  Williams, C. et al. 2010. Dev. Biol. 341: 196-204.

Citaciones 1 a 6 de un total de 6
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