PluriSln 1 A SCD1 inhibitor and apoptosis inducer

PluriSln 1 (CAS 91396-88-2)

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Sinónimo: 4-Pyridinecarboxylic acid 2-phenylhydrazide
Solicitud: A SCD1 inhibitor and apoptosis inducer
Número de CAS: 91396-88-2
Peso Molecular: 213.24
Fórmula Molecular: C12H11N3O
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PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic reticulum stress, reduces protein synthesis, and prevents teratoma formation in immunocompromised mice models.


References

1. Ben-David, Uri., et al., 2013. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell stem cell. 12(2): 167-79. PMID: 23318055

Estado de Materia :
Solid
ALMACENAMIENTO :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
225362
SMILES :
C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2

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