PGE2 An extremely important eicosanoid involved in neuronal, metabolic, and immune system function

PGE2 (CAS 363-24-6)

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Sinónimo: Prostaglandin E2; Dinoprostone; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
Solicitud: An extremely important eicosanoid involved in neuronal, metabolic, and immune system function
Número de CAS: 363-24-6
Pureza: ≥98%
Peso Molecular: 352.47
Fórmula Molecular: C20H32O5
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Prostaglandin E2 (PGE2) is the most physiologically abundant eicosanoid, which is produced predominantly from arachidonic acid (sc-200770) by COX and PGES, and exists at some level in nearly all cell types. PGE2 acts on four different receptors termed EP1 through EP4 yielding an astounding array of biological effects. Reported effects include: potent vasodilation, smooth muscle relaxation, both anti- and pro-inflammatory activities, stimulates bone resorption, synergizes with LTB4, facilitates replication of AIDS virus, regulates sleep/wake cycle, demonstrates thermoregulatory action in the CNS, induces LHRH release from rat median eminence, demonstrates a protective effect on gastric mucosa, and regulates renal hemodynamics and sodium excretion.


References

1. Raisz, L G., et al., 1977. Effect of prostaglaidin endoperoxides and metabolites on bone resorption in vitro. Nature. 267(5611): 532-4. PMID: 876371
2. Richardson, P D., et al., 1976. The vasodilator actions of isoprenaline, histamine, prostaglandin E2, glucagon and secretin on the hepatic arterial vascular bed of the dog. British journal of pharmacology. 57(4): 581-8. PMID: 963344
3. Christman, J W., et al., 1991. Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages. Prostaglandins. 41(3): 251-62. PMID: 1852897
4. Gerozissis, K., et al., 1991. Prostaglandin E2 and leukotriene C4-induced luteinizing hormone-releasing hormone release from immature and adult male rat median eminences in vitro: eicosanoid formation and binding parameters. Prostaglandins. 41(4): 345-57. PMID: 1871376
5. Long, C R., et al., 1990. Prostaglandin E2 induced changes in renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat. Prostaglandins. 40(6): 591-601. PMID: 2093936
6. Raud, J., et al., 1988. Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release. Proceedings of the National Academy of Sciences of the United States of America. 85(7): 2315-9. PMID: 2451246
7. Archer, C B., et al., 1987. Delayed-onset synergism between leukotriene B4 and prostaglandin E2 in human skin. Prostaglandins. 33(6): 799-805. PMID: 2823313
8. Kuno, S., et al., 1986. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83(10): 3487-90. PMID: 3010301
9. Hayaishi, O., et al., 1988. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of biological chemistry. 263(29): 14593-6. PMID: 3049580
10. Kuno, S., et al., 1986. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. Proceedings of the National Academy of Sciences of the United States of America. 83(8): 2682-3. PMID: 3458226
11. Miller, T A., et al., 1983. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. The American journal of physiology. 245(5 Pt 1): G601-23. PMID: 6195926

Estado de Materia :
Solid
Solubilidad :
Soluble in acetone, ethanol (50 mg/ml), DMSO (50 mg/ml), water (Partly miscible), DMF (100 mg/ml), PBS, pH 7.2 (5 mg/ml), and ethyl acetate.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
67-69° C
Punto de ebullición :
530.07° C at 760 mmHg
Densidad :
1.15 g/cm3
Indice de Refracción :
n20D 1.56
Actividad Óptica :
α20/D -85.5°, c = 1 in ethanol
IC50 :
MAP kinase: IC50 = 25-50 µM (rat mesangial cells)
Valores de pK :
pKa: 4.76
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
UK8000000
PubChem CID :
9691
Indice de Merck :
14: 7877
Número MDL :
MFCD00077861
Número EC :
206-656-6
Registro Beilstein :
4709356
SMILES :
CCCCC[C@@H](C=C[C@H]1[C@@H](CC(=O)[C@@H]1CC=CCCCC(=O)O)O)O

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PGE2  Menciones del Producto

Ver como otros han utilizado PGE2. Haga click en la entrada de PubMed .

Citaciones 1 a 10 de un total de 10

PMID: # 26610166  Nilsson, M. et al. 2016. Scandinavian journal of gastroenterology. 51: 538-47.

PMID: # 27020962  Bender, BF. et al. 2016. Lab on a chip. 16: 1505-13.

PMID: # 25510471  Aijian, AP. et al. 2015. Journal of laboratory automation. 20: 283-95.

PMID: # 24505138  He, L. et al. 2014. J. Biol. Chem. 289: 8019-28.

PMID: # 25184246  Dolkart, O. et al. 2014. The American journal of sports medicine. 42: 2869-76.

PMID: # 24586238  Clemente, MI. et al. 2014. PLoS ONE. 9: e85230.

PMID: # 23090667  Charo, C. et al. 2013. Pancreas. 42: 467-474.

PMID: # 22402965  Gu, G. et al. 2012. Biol. Reprod. 86: 159, 1-10.

PMID: # 23106460  Waldherr, K. et al. 2012. Am. J. Vet. Res. 73: 1752-1758.

PMID: # 8390534  Snijdewint, FG. et al. 1993. J. Immunol. 150: 5321-5329.

Citaciones 1 a 10 de un total de 10
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