MC 1293 inhibits maize histone deacetylase HD2 (IC50 = 1.9 μM) and histone deacetylase 1(HDAC1, IC50 = 4.5 μM). HDACs play a major role in histone modification.
1. Massa, S., et al., 2001. 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. Journal of medicinal chemistry. 44(13): 2069-72. PMID: 11405644 2. Mai, Antonello., et al., 2002. Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. Journal of medicinal chemistry. 45(9): 1778-84. PMID: 11960489
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