Glucocorticoid Receptor Modulator, CpdA A cell-permeable aziridine precursor

Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0)

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Sinónimo: 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
Solicitud: A cell-permeable aziridine precursor
Número de CAS: 14593-25-0
Pureza: ≥97%
Peso Molecular: 264.15
Fórmula Molecular: C11H14ClNO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.

Estado de Materia :
Solid
Solubilidad :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), and water (1 mg/ml).
ALMACENAMIENTO :
Store at -80° C
Punto de Fusión :
184-191° C
Indice de Refracción :
n20D ~1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9838147
Número MDL :
MFCD16883076
SMILES :
CC(=O)OC1=CC=C(C=C1)C(CNC)Cl.Cl

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CERTIFICADO DE ANÁLISIS

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Glucocorticoid Receptor Modulator, CpdA  Menciones del Producto

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PMID: # 25389358  Malaise, O. et al. 2015. Rheumatology (Oxford). 54: 1087-92.

Citaciones 1 a 1 de un total de 1
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