Diosmin Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyperpressure. Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1).

Diosmin  (CAS 520-27-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 48ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Sinónimo: 3’,5,7-Trihydroxy-4’-methoxyflavone 7-rutinoside
Solicitud: A flavonoid glycoside that reduces venous hyperpressure
Número de CAS: 520-27-4
Pureza: ≥95%
Peso Molecular: 608.5
Fórmula Molecular: C28H32O15
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
submit a review for this product and receive 15 cruzcredits

Información sobre pedidos

NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGO UNIDAD PRECIO CANTIDAD Favoritos
Diosmin sc-204728 5 g $33.00
Diosmin sc-204728A 25 g $98.00

Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyperpressure. Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.


References

Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum 35, 1085 (1992) Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res. 26, 395 (1992) Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol. 45, 1531 (1993) Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol. 111, 978 (1994) Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology 48, 45 (1997) Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer 73, 719 (1997) Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res. 58, 2754 (1998) Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett. 133, 135 (1998) Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie 54, 298 (1999) Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med. 65, 651 (1999) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol. 128, 539 (2002) The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg. 104, 715 (2004) Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem. 53, 6791 (2005)

Apariencia :
Powder
Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
ALMACENAMIENTO :
Store at 4° C
Punto de Fusión :
274° C (dec.)
Punto de ebullición :
~926.8° C at 760 mmHg (Predicted)
Densidad :
~1.7 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.71 (Predicted)
Actividad Óptica :
α20/D -121º±5º, c = 0.5 in 0.1 mol/l NaOH
Valores de pK :
pKa: 6.1 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
5281613
Indice de Merck :
14: 3297
Número MDL :
MFCD00009772
Número EC :
208-289-7
SMILES :
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

Puede que le guste también

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 79ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. es un líder mundial en el desarrollo de productos para el mercado de la investigación biomédica. Llámenos gratis al 00 800 4573 8000.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved."Santa Cruz Biotechnology", y el logo de Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", el logo de San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", y "EZ Touch" son marcas registradas de Santa Cruz Biotechnology, Inc. Todas las marcas registradas son propiedad de su respectivo dueño.