Cdk1/2 Inhibitor III A cell-permeable triazolo-diamine compound and ATP inhibitor

Cdk1/2 Inhibitor III (CAS 443798-55-8)

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Sinónimo: 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Solicitud: A cell-permeable triazolo-diamine compound and ATP inhibitor
Número de CAS: 443798-55-8
Pureza: >95%
Peso Molecular: 425.44
Fórmula Molecular: C15H13F2N7O2S2
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Cdk1/2 Inhibitor III is a cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Cdk1/2 Inhibitor III acts as a highly potent, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3b (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM)


References

1. Lin, Ronghui., et al., 2005. 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. Journal of medicinal chemistry. 48(13): 4208-11. PMID: 15974571

Estado de Materia :
Solid
Solubilidad :
DMSO
ALMACENAMIENTO :
Store at 4° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
5330812
SMILES :
C1=CC(=C(C(=C1)F)NC(=S)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F

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