AMD3100 octahydrochloride A specific CXCR4 antagonist

AMD3100 octahydrochloride (CAS 155148-31-5)

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Sinónimo: 1,1'-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
Solicitud: A specific CXCR4 antagonist
Número de CAS: 155148-31-5
Pureza: ≥98%
Peso Molecular: 794.47
Fórmula Molecular: C28H54N88HCl
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AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells.


References

1. Datema, R., et al., 1996. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial agents and chemotherapy. 40(3): 750-4. PMID: 8851605
2. , ., et al., 2007. Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791. Drugs in R&D. 8(2): 113-9. PMID: 17324009
3. Kim, Minah., et al., 2010. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer research. 70(24): 10411-21. PMID: 21056990

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (<1 mg/mL), water (100 mg/mL), and ethanol (<1 mg/mL).
ALMACENAMIENTO :
Desiccate at -20° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
65014
SMILES :
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3

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AMD3100 octahydrochloride  Menciones del Producto

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Citaciones 1 a 5 de un total de 5

PMID: # 25351811  Li, X. et al. 2015. Biotechnology letters. 37: 511-21.

PMID: # 24085800  Wang, B. et al. 2014. Carcinogenesis. 35: 282-91.

PMID: # 25157648  Wang, Y. et al. 2014. Molecular pharmaceutics. 11: 3463-70.

PMID: # 22688512  Asano, S. et al. 2012. Molecular and cellular biology. 32: 3242-52.

PMID: # 21850188  Liu, G. et al. 2011. Mol. Vis. 17: 2129-2138.

Citaciones 1 a 5 de un total de 5
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