Santa Cruz Biotechnology is expanding our monoclonal antibody product line. We offer monoclonal antibodies directed against proteins involved in transcription regulation, representing essentially all targets covered by polyclonal antibodies. To maintain homeostasis and to appropriately adapt to various changes, the cell must constantly produce the necessary gene products. Signal cascades transmit molecular messages leading to transcription factor activation and nuclear localization. Transcription factors bind to sequence-specific regions of DNA where they may act to promote or repress gene expression.