Topo Inhibitors

Santa Cruz Biotechnology now offers a broad range of Topo Inhibitors. DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Topo Inhibitors offered by Santa Cruz inhibit Topo and, in some cases, other DNA replication and recombination related proteins. View detailed Topo Inhibitor specifications, including Topo Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

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PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Gatifloxacin
A fluoroquinolone antibiotic and inhibitor of type II bacterial topoisomerases
112811-59-3 sc-204762
sc-204762A
1 g
5 g
$60.00
$260.00
13
Rufloxacin Hydrochloride
A fluoroquinolone antibacterial
106017-08-7 sc-202326
sc-202326A
50 mg
250 mg
$50.00
$200.00
1
Tosufloxacin tosylate
An antibacterial agent that inhibits bacterial DNA gyrase inhibitor
115964-29-9 sc-204920
sc-204920A
250 mg
1 g
$98.00
$294.00
0
9Z,11E,13E-Octadecatrienoic Acid ethyl ester
A conjugated polyunsaturated fatty acid
42021-86-3 sc-205198
sc-205198A
1 mg
100 mg
$90.00
$220.00
0
Doxorubicin hydrochloride
A Topo II inhibitor, DNA intercalator and powerful cytotoxic agent
25316-40-9 sc-200923
sc-200923B
sc-200923A
5 mg
10 mg
25 mg
$77.00
$140.00
$309.00
11
Camptothecin
A reversible Mitochondrial Topo I inhibitor shown to exhibit antitumor activity
7689-03-4 sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$46.00
$168.00
$80.00
12
Suramin sodium
A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5
129-46-4 sc-200833
sc-200833A
sc-200833B
50 mg
250 mg
1 g
$36.00
$143.00
$540.00
6
SN 38
The active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)
86639-52-3 sc-203697
sc-203697A
sc-203697B
10 mg
50 mg
500 mg
$109.00
$323.00
$860.00
6
beta-Lapachone
A selective DNA topoisomerase I inhibitor
4707-32-8 sc-200875
sc-200875A
5 mg
25 mg
$77.00
$324.00
6
Etoposide (VP-16)
Inhibits DNA synthesis via topoisomerase II inhibition
33419-42-0 sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$25.00
$154.00
$325.00
25
Mitoxantrone Dihydrochloride
Induces DNA damage by intercalating into DNA and inhibiting Topo II
70476-82-3 sc-203136
sc-203136A
10 mg
50 mg
$31.00
$57.00
3
Celastrol, Celastrus scandens
An antiproliferative, antipreroxidative, and inhibits Topo II
34157-83-0 sc-202534
10 mg
$152.00
5
Epirubicin Hydrochloride
A cell-permeable Topo II inhibitor
56390-09-1 sc-203041
5 mg
$147.00
0
Topotecan Hydrochloride
A water-soluble inhibitor of DNA Topo I
119413-54-6 sc-204919
sc-204919A
1 mg
5 mg
$34.00
$93.00
0
Ellipticine
A DNA intercalating inhibitor of Topo II
519-23-3 sc-200878
sc-200878A
10 mg
50 mg
$104.00
$430.00
1
Moxifloxacin Hydrochloride
An antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV
186826-86-8 sc-205758
sc-205758A
100 mg
500 mg
$116.00
$440.00
9
(S)-10-Hydroxycamptothecin
A camptothecin derivative that inhibits DNA topoisomerase I
19685-09-7 sc-205614
sc-205614A
25 mg
100 mg
$58.00
$165.00
1
SN-38-d3
A metabolite of Irinotecan, a DNA topoisomerase inhibitor
718612-49-8 sc-208392
1 mg
$700.00
0
Pirarubicin
An anti-neoplastic and inhibitor of Topo II
72496-41-4 sc-205810
sc-205810A
5 mg
10 mg
$170.00
$300.00
0
7-Ethyl Camptothecin
An anti-cancer agent and Topo I inhibitor
78287-27-1 sc-207171
10 mg
$188.00
0
Amonafide
A DNA intercalator and topoisomerase II inhibitor
69408-81-7 sc-207283
10 mg
$216.00
0
11-Ethyl Camptothecin
A substituted Topo I inhibitor
185807-29-8 sc-213584
10 mg
$31,500.00
0
7-Ethyl-d3-camptothecin
A deuterium labeled Topo I inhibitor
78287-27-1 (unlabeled) sc-217437
1 mg
$450.00
0
Amonafide-d6
A Topo II inhibitor and an antitumor agent
69408-81-7 (unlabeled) sc-217636
1 mg
$280.00
0
Ofloxacin
An antibacterial Topo II and Topo IV inhibitor
82419-36-1 sc-219475
10 g
$221.00
0
(R)-7-Ethyl Camptothecin
A R-Camptothecin derivative and Topo I inhibitor
1217633-65-2 sc-219741
1 mg
$280.00
0
Genistein-2prime,3prime,5prime,6prime-d4
A protein kinase inhibitor
187960-08-3 sc-280728
1 mg
$280.00
0
Dexrazoxane
An inhibitor of Topo II
24584-09-6 sc-252669
5 mg
$70.00
0
Razoxane
An inhibitor of Topo II
21416-67-1 sc-253425
sc-253425A
5 mg
25 mg
$72.00
$288.00
0
(+)-Irinotecan
A Topo I inhibitor
97682-44-5 sc-269253
10 mg
$60.00
0
Epirubicin
A cell permeable Topo II inhibitor
56420-45-2 sc-279016
25 mg
$450.00
0
1,4-Naphthoquinone
A chemical studied as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities as well as acetyltransferase activity
130-15-4 sc-237768
sc-237768A
100 g
250 g
$34.00
$40.00
0
trovafloxacin mesylate
A fluoroquinolone antibiotic and Topo IV inhibitor
147059-75-4 sc-280171
sc-280171A
sc-280171B
100 mg
10 mg
50 mg
$1,200.00
$155.00
$490.00
0
Genistein-2prime,6prime-d2
A labeled form of genistein
315204-48-9 sc-280729
1 mg
$220.00
0
Irinotecan Carboxylate Sodium Salt
A carboxylated Topo I inhibitor
sc-280848
5 mg
$280.00
0
Irinotecan-d10 Hydrochloride
A deuterated DNA Topo I inhibitor
718612-62-5 sc-280849
sc-280849A
1 mg
10 mg
$250.00
$2,000.00
7
Sodium Camptothecin
The salt form of Camptothecin
25387-67-1 sc-338592
1 g
$700.00
0
Genistein
A highly specific inhibitor of protein tyrosine kinase (PTK)
446-72-0 sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$25.00
$90.00
$118.00
$304.00
$490.00
$890.00
$1,785.00
20
Irinotecan Labeled d10
A deuterated DNA Topo I inhibitor
97682-44-5 (unlabeled) sc-353632
10 mg
$2,540.00
0
Temafloxacin Hydrochloride
A fluoroquinolone antibiotic
105784-61-0 sc-475068
25 mg
$395.00
0
Topotecan Hydrochloride Labeled d6
An isotope labeled Topo I inhibitor
119413-54-6 (unlabeled) sc-356167
10 mg
$2,000.00
0
BNS-22
A potent 2H-chromen-2-one small molecule inhibitor of Topo II
1151668-24-4 sc-364676
10 mg
$193.00
0

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