Potassium Channel Modulators

Santa Cruz Biotechnology now offers a broad range of Potassium Channel Modulators. Potassium Channel Modulators include any agent that blocks, activates, or modifies a potassium channel resulting in an alteration of the flow of potassium through the channel. Potassium channels are ubiquitous in biological systems and function as a control for the resting potential of cells. Potassium channels are notably important in neuronal and muscular cells, and their dysfunction has implications in many diseases including diabetes. Our popular products such as Glyburide (Glibenclamide), Tolazamide, and Flupirtine Maleate are typically available for immediate shipment.

indicates a highly recommended product based on customer preference.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Glyburide (Glibenclamide)
An ATP-dependent KIR6 and CFTR Cl- channel blocker
10238-21-8 sc-200982
sc-200982A
1 g
5 g
$32.00
$50.00
18
Neuropeptide Y
A potassium channel blocker, potent vasoconstrictor and reversible inhibitor of Ca2+-activated K+ channels
90880-35-6 sc-3140
0.5 mg
$89.00
4
Flupirtine Maleate
An indirect NMDA antagonist and Potassium channel activator
75507-68-5 sc-218512
10 mg
$99.00
0
Paxilline
A selective and reversible calcium-activated potassium channel blocker
57186-25-1 sc-3588
sc-3588A
5 mg
25 mg
$200.00
$409.00
14
Tetraethylammonium chloride
A small molecule blocker of K+ channels
56-34-8 sc-202834
25 g
$43.00
0
Chlorpromazine, Hydrochloride
An inhibitor of PDE, D2DR, NOS1, and PLA2
69-09-0 sc-202537
sc-202537A
sc-202537B
sc-202537C
sc-202537D
500 mg
5 g
25 g
100 g
250 g
$32.00
$48.00
$140.00
$480.00
$1,060.00
1
Apamin
A potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel
24345-16-2 sc-200994
sc-200994A
500 µg
1 mg
$155.00
$265.00
2
R-(+)-DIOA
An inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system
81166-47-4 sc-203230
sc-203230A
5 mg
25 mg
$140.00
$630.00
1
ICA 069673
A selective activator of the KCNQ2/Q3 potassium channel
582323-16-8 sc-362745
sc-362745A
10 mg
50 mg
$159.00
$645.00
0
4-Aminopyridine
A nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane
504-24-5 sc-202421
sc-202421A
sc-202421B
25 g
100 g
1 kg
$36.00
$118.00
$1,110.00
2
TRAM-34
An inhibitor of IKCa1 channels and a cell proliferation modulator
289905-88-0 sc-201005
sc-201005A
5 mg
25 mg
$100.00
$190.00
5
Astemizole
A potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity
68844-77-9 sc-201088
sc-201088A
10 mg
50 mg
$69.00
$275.00
0
5-Hydroxydecanoate sodium salt
An inhibitor of ATP-sensitive K+ channels
71186-53-3 sc-200992
sc-200992A
100 mg
500 mg
$79.00
$284.00
2
Dronedarone HCl
A calcium channlel protein inhibitor
141625-93-6 sc-362060
10 mg
$150.00
0
Tolbutamide
A hypoglycemic agonist for secretion of islet hormones
64-77-7 sc-203298
5 g
$35.00
1
Diazoxide
A selective ATP-dependent K<sup>+</sup> (Kir6) channel activator
364-98-7 sc-200980
1 g
$224.00
1
1-EBIO
A potassium channel modulator of epithelial KCa channels
10045-45-1 sc-201695
sc-201695A
10 mg
50 mg
$85.00
$319.00
1
Pinacidil monohydrate
A K+ channel activator
85371-64-8 sc-203198
sc-203198A
10 mg
50 mg
$20.00
$53.00
2
(-)-[3R,4S]-Chromanol 293B
A selective inhibitor of the slow component of delayed rectifier K+ current
163163-24-4 sc-361081
sc-361081A
10 mg
50 mg
$135.00
$599.00
0
BMS 191011
An opener of cloned large-conductance, Ca2+-activated potassium channel
202821-81-6 sc-203847
sc-203847A
10 mg
50 mg
$185.00
$750.00
0
Dequalinium chloride
A selective blocker of apamin-sensitive K+ channels
522-51-0 sc-214869
sc-214869A
5 g
500 mg
$129.00
$51.00
1
Quinine hemisulfate
A Stereoisomer of quinidine
6119-70-6 sc-202305
10 g
$50.00
0
Quinidine hydrochloride monohydrate
A potassium channel blocker
6151-40-2 sc-215772
sc-215772A
5 g
10 g
$38.00
$69.00
0
Verruculogen
A neurotoxin that inhibits the M phase of the mammalian cell cycle
12771-72-1 sc-204939
sc-204939A
1 mg
5 mg
$112.00
$278.00
0
U-37883A
A potent inhibitor of vascular smooth muscle KIR6 channels
57568-80-6 sc-201001
sc-201001A
5 mg
25 mg
$77.00
$309.00
1
Docosahexaenoyl Ethanolamide
An ethanolamine amide of DHA
162758-94-3 sc-221563
sc-221563A
5 mg
10 mg
$61.00
$105.00
0
NS 1643
An antiarrhythmic activator of hERG K+ channels
448895-37-2 sc-204135
sc-204135A
10 mg
50 mg
$67.00
$357.00
2
(-)-Bicuculline methiodide
A N-methylated derivative of the GABAA antagonist (+)-bicuculline
40709-69-1 sc-200485
50 mg
$142.00
5
S-(+)-Niguldipine hydrochloride
A calcium channel protein inhibitor
113165-32-5 sc-203248
10 mg
$124.00
0
PCO 400
An analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener
121055-10-5 sc-200989
sc-200989A
20 mg
100 mg
$53.00
$213.00
0
SKF 96365
A calcium channel protein and Stim 1 inhibitor
130495-35-1 sc-201475
sc-201475A
5 mg
25 mg
$99.00
$381.00
0
AM 92016 hydrochloride
A specific blocker of the time dependent delayed rectifier potassium current
178894-81-0 sc-203506
sc-203506A
10 mg
50 mg
$165.00
$595.00
0
Aprindine hydrochloride
An hERG channel blocker
33237-74-0 sc-252383
10 mg
$123.00
0
L-364,373
An activator of KCNQ1 (KVLQT1) channels
103342-82-1 sc-204036
sc-204036A
10 mg
50 mg
$209.00
$880.00
0
CP 339818 hydrochloride
A non-peptide and inhibitor of Kv1.3
185855-91-8 sc-203903
sc-203903A
10 mg
50 mg
$155.00
$660.00
0
UCL 1684 ditrifluoroacetate
A potent, non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel
201147-19-5 sc-253818
5 mg
$209.00
1
Paxillinol
sc-205792
2 mg
$150.00
0
Tertiapin LQ
A tertiapin-Q derivative that blocks Kir1.1 channels
sc-362807
1 mg
$175.00
0
Rutaecarpine
An inhibitor of Cox-2 and platelet aggregation
84-26-4 sc-205846
sc-205846A
10 mg
25 mg
$123.00
$359.00
1
Doxapram
A central respiratory stimulant
309-29-5 sc-279007
5 mg
$100.00
0
Adenosine 5prime-Triphosphate, disodium salt
A p2 purinergicagonist
987-65-5 sc-202040
sc-202040A
1 g
5 g
$25.00
$54.00
9
Rose Bengal lactone
A useful dye
4159-77-7 sc-219991
1 g
$85.00
0
Isopimaric Acid
Potent Ca-activated K+ channel opener
5835-26-7 sc-269270
5 mg
$69.00
0
Quinine hydrochloride dihydrate
A Potassium channel blocker
6119-47-7 sc-212619
sc-212619A
5 g
25 g
$47.00
$158.00
0
Quinidine sulfate dihydrate
A Na+ channel blocker
6591-63-5 sc-205967
5 g
$60.00
0
Penitrem A
A selective and irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ channel
12627-35-9 sc-200997
sc-200997A
1 mg
5 mg
$51.00
$145.00
2
Tolfenamic Acid
A non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
13710-19-5 sc-204918
sc-204918A
5 g
25 g
$68.00
$306.00
0
BL-1249
A putative activator of potassium TREK-1 channel
18200-13-0 sc-252498
10 mg
$175.00
0
Gliclazide
A hypoglycemic agent
21187-98-4 sc-211561
1 g
$60.00
0
Glipizide
A hypoglycemic agent that enhances insulin secretion
29094-61-9 sc-204768
sc-204768A
1 g
5 g
$35.00
$112.00
0
Minoxidil (U-10858)
A selective ATP dependent K+ (Kir6) channel activator
38304-91-5 sc-200984
sc-200984A
100 mg
1 g
$67.00
$120.00
0
Cibenzoline
CAS: 53267-01-9, MF: C18H18N2, MW: 262.356, Purity: ≥95%
53267-01-9 sc-268718
10 mg
$200.00
0
(-)-Bicuculline methochloride
A water-soluble GABAA antagonist
53552-05-9 sc-203528
sc-203528A
10 mg
50 mg
$109.00
$323.00
0
P1075
A potent KATP (Kir6) channel opener
60559-98-0 sc-203657
sc-203657A
10 mg
50 mg
$195.00
$825.00
0
Gabapentin-lactam
A potassium channel modulator and potential neuroprotector
64744-50-9 sc-201003
sc-201003A
50 mg
250 mg
$64.00
$196.00
0
Nicorandil
A small molecule KATP (Kir6) channel opener and NO donor
65141-46-0 sc-200995
sc-200995A
sc-200995B
sc-200995C
50 mg
250 mg
100 mg
1 g
$57.00
$240.00
$98.00
$500.00
3
Adenylyl-imidodiphosphate, Tetralithium Salt
A competitive inhibitor of ATP-dependent enzymes
72957-42-7 sc-203805
25 mg
$245.00
0
CyPPA
An activator of small conductance Ca2+ activated K+ channels
73029-73-9 sc-205281
sc-205281A
10 mg
50 mg
$145.00
$645.00
0
alpha-Dendrotoxin
An inducer of acetylcholine release at neuromuscular junction
74504-53-3 sc-252333
0.1 mg
$420.00
0
Minoxidil sulfate (U-58838)
A K+ channel agonist and a strong vascular smooth muscle relaxant
83701-22-8 sc-200987
sc-200987A
sc-200987B
sc-200987C
5 mg
25 mg
50 mg
100 mg
$90.00
$309.00
$480.00
$950.00
0
(+/-)-Cromakalim
A prototypical Kir6 (KATP) channel activator
94470-67-4 sc-217958
25 mg
$325.00
0
Levcromakalim
An active enantiomer of the prototypical KATP(Kir6) channel opener cromakalim
94535-50-9 sc-361230
sc-361230A
10 mg
50 mg
$225.00
$928.00
1
Charybdotoxin
A potent and selective inhibitor of the large conductance Ca2+-activated K+ channels
95751-30-7 sc-200979
100 µg
$224.00
9
Linopirdine dihydrochloride
A KCNQ (Kv7) blocker
113168-57-3 sc-204058
sc-204058A
10 mg
50 mg
$165.00
$700.00
0
E-4031 dihydrochloride
A K+ channel blocker that spawned a class of antiarrhythmic molecules
113559-13-0 sc-203034
5 mg
$154.00
0
XE 991 dihydrochloride
A potent & selective inhibitor of KCNQ voltage-gated K-channels
122955-42-4 sc-203453
sc-203453A
10 mg
50 mg
$165.00
$700.00
0
Y-26763
A KATP (Kir6) channel opener
127408-31-5 sc-204406
sc-204406A
10 mg
50 mg
$175.00
$709.00
0
Repaglinide
A KIR6 (KATP) channel blocker
135062-02-1 sc-219959
100 mg
$126.00
0
UK-78282 monohydrochloride
An inhibitor of Kv1.3 and Kv1.4 potassium channels
136647-02-4 sc-253820
5 mg
$119.00
0
Kaliotoxin
A highly selective, high conductance Ca2+-activated Kv1.1 and Kv1.3 blocker
145199-73-1 sc-362754
10 µg
$98.00
0
Mitiglinide Calcium
A closer of K+-ATP channels
145375-43-5 sc-204808
sc-204808A
100 mg
250 mg
$168.00
$315.00
0
ZM 226600
A potent Kir6 (KATP) channel opener
147695-92-9 sc-281189
sc-281189A
10 mg
50 mg
$89.00
$348.00
0
NS-1619
A selective large conductance calcium activated potassium channel activator
153587-01-0 sc-200986
5 mg
$106.00
1
LY 303511
A negative control for PI 3-kinase inhibitors
154447-38-8 sc-202215
sc-202215A
1 mg
5 mg
$65.00
$268.00
3
Chromanol 293B
A blocker of the slow delayed rectifier K+ current
163163-23-3 sc-203889
sc-203889A
10 mg
50 mg
$155.00
$670.00
0
UCL-1848 trifluoroacetate salt
201147-53-7 sc-253819
sc-253819A
5 mg
25 mg
$151.00
$500.00
0
VU 590 dihydrochloride
An inhibitor of the renal, outer medullary potassium channel, KIR7.1
313505-85-0 sc-358792
sc-358792A
10 mg
50 mg
$109.00
$440.00
0
CP-339818
A compound blocking both Kv1.3 and Kv1.4
478341-55-8 sc-252641
5 mg
$62.00
0
GW 542573X
A small-conductance Ca2+-activated K+ channel activator
660846-41-3 sc-362741
sc-362741A
10 mg
50 mg
$175.00
$739.00
0
Psora-4
A potassium channel modulator
724709-68-6 sc-253325
5 mg
$159.00
0
5-(4-Phenoxybutoxy)psoralen
A selective inhibitor of Kv1.3, voltage-gated potassium channel
870653-45-5 sc-252247
sc-252247A
5 mg
25 mg
$114.00
$700.00
0
UCL 2077
A slow afterhyperpolarization channel blocker
918311-87-2 sc-204371
sc-204371A
10 mg
50 mg
$135.00
$575.00
0
Tetraethylammonium bromide
71-91-0 sc-251173
sc-251173A
25 g
250 g
$78.00
$167.00
0
PD-118057
An activator of ether-a-go-go-related (hERG) potassium channel
313674-97-4 sc-253238
5 mg
$196.00
0
Potassium dicyanoargentate
CAS: 506-61-6, MF: C2AgKN2, MW: 199.00
506-61-6 sc-253300
10 g
$35.00
0
N-Salicyloyltryptamine
31384-98-2 sc-253124
5 mg
$88.00
0
Alinidine
33178-86-8 sc-252357
sc-252357A
10 mg
100 mg
$98.00
$600.00
0
YS-035 hydrochloride
A Ca2+ blocker and inhibitor of outward K+ currents
33978-72-2 sc-203722
sc-203722A
10 mg
50 mg
$115.00
$485.00
0
DPO-1
A blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current
43077-30-1 sc-203570
sc-203570A
10 mg
50 mg
$159.00
$670.00
0
SG 209
A K+-channel opener
83440-03-3 sc-204276
sc-204276A
10 mg
50 mg
$90.00
$395.00
0
Sematilide monohydrochloride monohydrate
101526-62-9 (non-salt) sc-253550
50 mg
$395.00
0
(S)-O-Methyl Patulin
A protected patulin
123251-09-2 sc-396452
10 mg
$300.00
0
Y-27152
A prodrug of the KATP (Kir6) channel opener Y-26763
127408-30-4 sc-204407
sc-204407A
10 mg
50 mg
$189.00
$796.00
0
Margatoxin
A specific blocker of Kv1.3, Kv1.6 channels
145808-47-5 sc-358754
100 µg
$144.00
0
DMP 543
A K+ channel blocker and acetylcholine release stimulator
160588-45-4 sc-203926
sc-203926A
10 mg
50 mg
$135.00
$595.00
0
NS 5806
An activator of the KV4.3 channel that mediates the transient outward K+ current (Ito)
426834-69-7 sc-362773
sc-362773A
5 mg
25 mg
$108.00
$425.00
0
Tetracaine hydrochloride
A calcium channel protein inhibitor
136-47-0 sc-251166
sc-251166A
5 g
25 g
$50.00
$91.00
0
Agitoxin
A small polypeptide, 38 amino acid residues, that acts as a potent inhibitor of the Shaker K+ channel
78207-24-6 sc-3582
5 µg
$94.00
0
Tolbutamide-d9
A labelled Tolbutamide and antidiabetic
1219794-57-6 sc-396112
2.5 mg
$280.00
0
Dofetilide-d4
A potassium channel blocker
sc-218264
1 mg
$300.00
0
Flupirtine-d4 Hydrochloride Salt
A labeled flupirtine compound
sc-218513
1 mg
$280.00
0
Glipizide-d11
A sulfonylurea hypoglycemic agent
1189426-07-0 sc-280738
1 mg
$250.00
0
Minoxidil-d10
An antihypertensive and antialopecia agent
38304-91-5 (unlabeled) sc-218853
5 mg
$300.00
0
NS8593 hydrochloride
A calcium channel modulator
875755-24-1 sc-253203
5 mg
$138.00
0
Sotalol-d6 Hydrochloride
A deuterium labeled β-adronergic blocker
1246820-85-8 sc-220127
1 mg
$280.00
0
Clofilium tosylate
A K+ channel blocker
92953-10-1 sc-391228
sc-391228A
25 mg
100 mg
$160.00
$650.00
0
Azimilide Dihydrochloride
149888-94-8 sc-503233
10 mg
$220.00
0

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