p53 Activators

Santa Cruz Biotechnology now offers a broad range of p53 Activators. p53 is a DNA-binding tumor suppressor, which upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 Activators offered by Santa Cruz activate p53 and, in some cases, other cell death and cell differentiation related proteins. View detailed p53 Activator specifications, including p53 Activator CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

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PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Actinomycin D
A potent antibiotic that binds to the GpC steps of DNA
50-76-0 sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$62.00
$224.00
$693.00
$2,462.00
$20,990.00
5
Camptothecin
A reversible Mitochondrial Topo I inhibitor shown to exhibit antitumor activity
7689-03-4 sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$46.00
$168.00
$80.00
12
Suberoyl bis-hydroxamic Acid
Inhibits histone deacetylation
38937-66-5 sc-200887
sc-200887A
100 mg
500 mg
$50.00
$104.00
0
Etoposide (VP-16)
Inhibits DNA synthesis via topoisomerase II inhibition
33419-42-0 sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$25.00
$154.00
$325.00
25
PRIMA-1MET
A methylated derivative of PRIMA-1 shown to restore mutant p53 activity
5291-32-7 sc-361295
sc-361295A
10 mg
25 mg
$135.00
$300.00
3
Tenovin-6
An inhibitor of SIRT1, SIRT2, and SIRT3 and activator of p53
1011557-82-6 sc-224296
sc-224296A
1 mg
5 mg
$262.00
$1,185.00
7
p53 Activator III, RITA
A trycyclic thiophene derivative that binds MDM2, activates p53 and induces apoptosis
213261-59-7 sc-202753
sc-202753A
sc-202753B
sc-202753C
1 mg
10 mg
100 mg
500 mg
$78.00
$220.00
$1,503.00
$5,000.00
5
Etoposide Phosphate
A topoisomerase II inhibitor inspired by podophyllotoxin
117091-64-2 sc-357357
sc-357357A
25 mg
100 mg
$135.00
$350.00
1
Tenovin-1
An inhibitor of SIRT1 and SIRT2
380315-80-0 sc-222342
10 mg
$85.00
0
Irinotecan hydrochloride trihydrate
An inhibitor of Topo I
136572-09-3 sc-202186
sc-202186A
5 mg
25 mg
$93.00
$341.00
6
JNJ 26854165
A p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor
881202-45-5 sc-364514
sc-364514A
5 mg
25 mg
$124.00
$555.00
0
HR-73
CAS: 959571-93-8, MF: C19H13BrO2, MW: 353.21, Purity: ≥98%
959571-93-8 sc-255207
5 mg
$156.00
0
CHS-828
A NAMPT and NF-κB pathway activity inhibitor
200484-11-3 sc-364106
sc-364106A
5 mg
25 mg
$84.00
$338.00
0
NSC 66811
6964-62-1 sc-311507
sc-311507A
10 mg
50 mg
$159.00
$670.00
0
Etoposide-d3
The labeled form of Etoposide
sc-218445
1 mg
$350.00
6
PRIMA-1
A reactivator of p53 and inducer of apoptosis
5608-24-2 sc-200927
sc-200927A
5 mg
25 mg
$64.00
$200.00
1
Vinblastine Sulfate
An anti-mitotic agent which arrests the cell cycle in the G2/M-phase
143-67-9 sc-201447
sc-201447A
10 mg
50 mg
$99.00
$390.00
8
Amifostine
A broad radio-chemoprotector that restores mutant p53 activity
20537-88-6 sc-200937
sc-200937A
10 mg
50 mg
$71.00
$294.00
4
Lomustine
An alkylating antitumor nitrosourea agent
13010-47-4 sc-202697
50 mg
$47.00
0
Deferoxamine mesylate
An iron chelator which induces apoptosis
138-14-7 sc-203331
1 g
$150.00
4
NSC 146109 hydrochloride
An antitumor activator of p53-dependent transcription
59474-01-0 sc-203652
10 mg
$149.00
0
MIRA-1
A restorer of wild-type p53 conformation and cellular function
72835-26-8 sc-204087
sc-204087A
10 mg
50 mg
$109.00
$429.00
0
Ascochlorin
An inhibitor of matrix metalloproteinase-9 activity
26166-39-2 sc-202066
500 µg
$359.00
0
CP 31398 dihydrochloride
Promotes activity of p53 in cancer cell lines
259199-65-0 sc-205270
sc-205270A
10 mg
50 mg
$107.00
$425.00
0
Salermide
An inhibitor of SIRT1, SIRT2, and HDAC
1105698-15-4 sc-224276
sc-224276A
5 mg
10 mg
$70.00
$105.00
2
Hydroxyurea
An inducer of apoptosis by inhibiting DNA synthesis via ribonucleotide reductase inhibition
127-07-1 sc-29061
sc-29061A
5 g
25 g
$65.00
$240.00
12
HLI 373
An apoptosis inducer and inhibitor of Hdm2 ubiquitin ligase
502137-98-6 sc-358833
sc-358833A
10 mg
50 mg
$155.00
$645.00
0
PNC-28
Induces non-apoptotic cell death independent of p53
sc-222123
500 µg
$300.00
0
p53 Activator II, Cell-Permeable
A cell-permeable p53-activating peptide that displays antitumor properties
sc-364561
500 µg
$299.00
0
p53 Activator, Cell-Permeable
A cell-permeable peptide that binds mutant p53
sc-364562
500 µg
$222.00
0
NSC-207895
An anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2.
58131-57-0 sc-364550
sc-364550A
5 mg
10 mg
$340.00
$640.00
0

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