Histone Modification

Santa Cruz Biotechnology now offers a broad range of Histone Modification products. Histones are proteins which help organize DNA into nucleosomes and affect which genes can be transcribed. These proteins can be modified in various ways, particularly acetylation, inducing widespread effects on gene expression which impact all areas of physiological functioning. The study of histone modification can be highly beneficial for understanding how damage, mutations, and alterations to some of the most basic units of life affect the progression of cancer and other genetically influenced diseases. Our popular products such as Suberoylanilide Hydroxamic Acid, Leptomycin B, and Valproic Acid, Sodium Salt are typically available for immediate shipment.

indicates a highly recommended product based on customer preference.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Tranylcypromine
An irreversible inhibitor of MAO and inhibitor of histone demethylation
13492-01-8 sc-200572
sc-200572A
1 g
5 g
$101.00
$415.00
2
Piceatannol
An inhibitor of Syk and NF-κB activation
10083-24-6 sc-200610
sc-200610A
1 mg
5 mg
$34.00
$62.00
6
Sodium phenylbutyrate
An HDAC inhibitor and caspase activator
1716-12-7 sc-200652
sc-200652A
sc-200652B
sc-200652C
sc-200652D
1 g
10 g
100 g
1 kg
10 kg
$64.00
$150.00
$600.00
$4,800.00
$31,500.00
11
ZM-447439
A selective inhibitor of ARK-1, ARK-2, and ARK-3
331771-20-1 sc-200696
sc-200696A
1 mg
10 mg
$67.00
$169.00
7
Resveratrol
A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1
501-36-0 sc-200808
sc-200808A
100 mg
500 mg
$53.00
$175.00
13
Suramin sodium
A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5
129-46-4 sc-200833
sc-200833A
sc-200833B
50 mg
250 mg
1 g
$36.00
$143.00
$540.00
6
HC Toxin
An HDAC inhibitor
83209-65-8 sc-200884
1 mg
$152.00
1
Suberoyl bis-hydroxamic Acid
Inhibits histone deacetylation
38937-66-5 sc-200887
sc-200887A
100 mg
500 mg
$50.00
$104.00
0
Garcinol
A potent p300 and PCAF histone acetyltransferase inhibitor
78824-30-3 sc-200891
sc-200891A
10 mg
50 mg
$90.00
$375.00
2
Chaetocin
A lysine-specific histone methyltransferase inhibitor
28097-03-2 sc-200893
200 µg
$90.00
3
ITSA1
An HDAC activator via TSA suppression
200626-61-5 sc-200894
sc-200894A
25 mg
100 mg
$88.00
$222.00
0
H1-7 (histone H1 phosphorylation site), PKA Substrate
A synthetic peptide PKA substrate
65189-70-0 sc-201152
1 mg
$61.00
0
Gliotoxin
A toxic epipolythiodioxopiperazine metabolite that induces apoptosis and inhibits NF-κB
67-99-2 sc-201299
sc-201299A
2 mg
10 mg
$124.00
$374.00
0
Dibutyryl-cAMP
An analog of cyclic AMP that stimulates cAMP-dependent protein kinase
16980-89-5 sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$37.00
$109.00
$400.00
$3,749.00
23
Apicidin
An HDAC inhibitor and apoptosis inducer
183506-66-3 sc-202061
sc-202061A
1 mg
5 mg
$64.00
$194.00
7
Sodium Butyrate
An HDAC inhibitor and apoptosis inducer
156-54-7 sc-202341
sc-202341A
sc-202341B
250 mg
25 g
5 g
$20.00
$70.00
$35.00
9
Valproic acid sodium salt
An HDAC inhibitor with anticancer, anti-inflammatory and neuroprotective effects
1069-66-5 sc-202378
5 g
$31.00
6
5-Aza-2prime-Deoxycytidine
A Dnmt inhibitor shown to alter gene expression
2353-33-5 sc-202424
25 mg
$200.00
1
Anacardic Acid
Shown to potently inhibit HAT-dependent transcription and SUMOylation
16611-84-0 sc-202463
sc-202463A
5 mg
25 mg
$41.00
$157.00
4
B2
A cell permeable inhibitor of SIRT2 (sirtuin 2)
115687-05-3 sc-202486
sc-202486A
500 µg
5 mg
$30.00
$102.00
0
Binucleine 2
An inhibitor of cytokinesis function of the ARK-2 pathway
220088-42-6 sc-202500
5 mg
$162.00
0
Butein
Inhibits the tyrosine kinase activity of the EGF receptor and p60c-src
487-52-5 sc-202510
sc-202510A
5 mg
50 mg
$169.00
$300.00
4
CTPB
A potent p300 HAT activator
586976-24-1 sc-202558
sc-202558A
1 mg
5 mg
$46.00
$148.00
2
Histone Lysine Methyltransferase Inhibitor
An HMTase inhibitor known as BIX-01294 Trihydrochloride
935693-62-2 (hydrate) sc-202651
5 mg
$145.00
1
Eosin Y Disodium Trihydrate
An inhibitor of PRMTs
17372-87-1 sc-202776
sc-202776A
sc-202776B
50 mg
500 mg
5 g
$20.00
$40.00
$80.00
1
Scriptaid
An HDAC1, HDAC3, and HDAC8 inhibitor
287383-59-9 sc-202807
sc-202807A
1 mg
5 mg
$62.00
$175.00
4
SIRT2 Inhibitor, AGK2
A reversible inhibitor of SIRT2 activity
304896-28-4 sc-202813
5 mg
$111.00
3
Aristoforin
A highly-stable SIRT inhibitor used for research purposes
849215-53-8 sc-202958
1 mg
$151.00
0
EX 527
A selective inhibitor of SIRT1 over SIRT2 and SIRT3
49843-98-3 sc-203044
5 mg
$80.00
11
M 344
A potent HDAC inhibitor with IC50 of 100 nM
251456-60-7 sc-203124
sc-203124A
1 mg
5 mg
$99.00
$304.00
8
MRN-ATM Pathway Inhibitor, Mirin
An inhibitor of Mre-11 and cell cycle arresting compound
299953-00-7 sc-203144
10 mg
$135.00
1
Quercetin Dihydrate
A natural flavonoid antiproliferative kinase inhibitor
6151-25-3 sc-203225
sc-203225A
5 g
25 g
$31.00
$39.00
1
Sangivamycin
A cytotoxic purine nucleoside
18417-89-5 sc-204261
1 mg
$185.00
0
SIRT1 Inhibitor IV, (S)-35
An inhibitor of SIRT1
848193-72-6 sc-204279
500 µg
$224.00
1
CI 994
An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor
112522-64-2 sc-205245
sc-205245A
10 mg
50 mg
$97.00
$525.00
1
NSC 3852
An inhibitor of HDAC (histone deacetylase)
3565-26-2 sc-205773
10 mg
$32.00
0
AMI-1, sodium salt
A PRMT and HIV-1 RT polymerase inhibitor
20324-87-2 sc-205928
sc-205928A
5 mg
25 mg
$96.00
$364.00
2
Oxamflatin
A potent inhibitor of HDACs (histone deacetylases)
151720-43-3 sc-205960
sc-205960A
1 mg
5 mg
$80.00
$299.00
1
Sirtinol
An inhibitor of Sir2, SIRT1, and SIRT2, but not HDAC1
410536-97-9 sc-205976
sc-205976A
1 mg
5 mg
$31.00
$104.00
11
N-(2-Aminophenyl)-N′-phenylheptanediamide
An HDAC inhibitor
537034-15-4 sc-207902
sc-207902A
10 mg
25 mg
$350.00
$810.00
0
trans 2-Phenylcyclopropylamine Hydrochloride
A non-selective inhibitor of MAO
1986-47-6 sc-208452
sc-208452A
250 mg
1 g
$40.00
$84.00
0
Acetyl coenzyme A sodium salt
An essential cofactor and carrier of acyl groups
102029-73-2 sc-210745
sc-210745A
1 mg
5 mg
$40.00
$69.00
0
APHA Compound 8
A synthetic HDAC (histone deacetylase) inhibitor
676599-90-9 sc-210828
1 mg
$84.00
0
Valproic Acid
A branched chain fatty acid
99-66-1 sc-213144
10 g
$70.00
1
Suberoylanilide Hydroxamic Acid
A potent HDAC inhibitor; also causes cell cycle arrest at G1
149647-78-9 sc-220139
100 mg
$115.00
21
Suberoylanilide-d5 Hydroxamic Acid
A potent, selective, and cell permeable HDAC inhibitor
149647-78-9 (unlabeled) sc-220140
1 mg
$300.00
0
BML-210
An inhibitor of HDAC activity and gene expression modulator
537034-17-6 sc-221369
sc-221369A
1 mg
5 mg
$77.00
$263.00
0
BML-266
A SIRT2 inhibitor
96969-83-4 sc-221371
sc-221371A
10 mg
50 mg
$102.00
$402.00
0
Histone Deacetylase
Useful for histone assays
sc-221728
2 ml
$244.00
0
MC 1293
An inhibitor of HDAC1 and maize histone deacetylase HD2
sc-221875
5 mg
$173.00
1
N-Myristoyl-Lys-Arg-Thr-Leu-Arg-OH
An inhibitor of histone phosphorylation
125678-68-4 sc-222009
1 mg
$48.00
0
Nullscript
A negative control for the HDAC inhibitor Scriptaid
300816-11-9 sc-222084
sc-222084A
1 mg
5 mg
$66.00
$258.00
0
Tenovin-1
An inhibitor of SIRT1 and SIRT2
380315-80-0 sc-222342
10 mg
$85.00
0
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
A selective HDAC1 inhibitor
193551-00-7 sc-223859
sc-223859A
1 mg
5 mg
$32.00
$144.00
0
HDAC6 Inhibitor
An inhibitor of HDAC6
1045792-66-2 sc-223877
sc-223877A
500 µg
1 mg
$61.00
$84.00
3
Salermide
An inhibitor of SIRT1, SIRT2, and HDAC
1105698-15-4 sc-224276
sc-224276A
5 mg
10 mg
$70.00
$105.00
2
Tenovin-6
An inhibitor of SIRT1, SIRT2, and SIRT3 and activator of p53
1011557-82-6 sc-224296
sc-224296A
1 mg
5 mg
$262.00
$1,185.00
7
4-(3,4-Dimethoxyphenyl)butyric acid
Has effects on apoptosis, proliferation and HDAC activity
13575-74-1 sc-226371
5 g
$54.00
0
Bufexamac
An HDAC6 and HDAC10 inhibitor
2438-72-4 sc-227537
10 g
$75.00
0
DL-Lysine-4,4,5,5-d4 dihydrochloride
A labeled amino acid derivative
284664-88-6 sc-234825
1 g
$1,095.00
0
BATCP
An HDAC 6 selective substrate
787549-23-9 sc-252405
2 mg
$109.00
0
PTACH
A potent HDAC inhibitor
848354-66-5 sc-253326
2 mg
$216.00
0
Trapoxin A
A cyclotetrapeptide HDAC inhibitor
133155-89-2 sc-253730
1 mg
$165.00
0
CPTH2
CAS: 357649-93-5, MF: C14H14ClN3S, MW: 291.80, Purity: ≥98%
357649-93-5 sc-255032
5 mg
$115.00
0
BIX01294 hydrochloride
A selective histone methyl transferase (HMTase) inhibitor.
1392399-03-9 sc-293525
sc-293525A
1 mg
5 mg
$35.00
$100.00
0
Curcumin (Synthetic)
Reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators
458-37-7 sc-294110
sc-294110A
5 g
25 g
$50.00
$150.00
1
Fmoc-L-Lys(Me2)-OH*HCl
A Lysine derivative used to study histone modification
252049-10-8 sc-294919
100 mg
$300.00
0
(S)-HDAC-42
A potent inhibitor of HDAC
935881-37-1 sc-296364
sc-296364A
1 mg
5 mg
$86.00
$395.00
0
AMI-1, free acid
A chemical shown to inhibit arginine, in vitro, with no inhibitory effect on lysine
134-47-4 sc-300192
1 g
$96.00
0
Boc-Lys(Tfa)-AMC
A fluorogenic substrate for the assaying of histone deacetylase 4, 5, 7
97885-44-4 sc-300290
sc-300290A
50 mg
250 mg
$200.00
$818.00
0
cGKI inhibitor
sc-3042
0.5 mg/0.1 ml
$89.00
0
PKA Substrate
A synthetic substrate for PKA
sc-3059
0.5 mg
$89.00
1
Cdk5 substrate
Derived from the Histone H1 peptide sequence docked in the active site of Cdk5
sc-3066
500 µg
$88.00
0
Daminozide
A KDM (LSD1) histone demethylase inhibitor
1596-84-5 sc-326749
sc-326749A
5 g
25 g
$31.00
$78.00
0
Trichostatin A
A potent and non-competitive reversible inhibitor of HDAC
58880-19-6 sc-3511
sc-3511A
1 mg
5 mg
$137.00
$456.00
18
Parthenolide
An inhibitor specifically inhibits HDAC1 without affecting other class I/II HDACs
20554-84-1 sc-3523
sc-3523A
50 mg
250 mg
$72.00
$294.00
18
Triacetylresveratrol
A resveratrol precursor and SIRT activator
42206-94-0 sc-358583
sc-358583A
1 g
5 g
$216.00
$772.00
0
Butyrolactone 3
A histone acetyltransferase GCN5 inhibitor
778649-18-6 sc-358657
sc-358657A
sc-358657B
5 mg
50 mg
100 mg
$141.00
$950.00
$1,650.00
1
Leptomycin B
A potent and specific nuclear export inhibitor that acts as an antifungal agent
87081-35-4 sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$98.00
$400.00
$1,200.00
10
Splitomicin
A Sir2p histone deactylease inhibitor
5690-03-9 sc-358701
5 mg
$46.00
0
Deacetylation Inhibition Cocktail
Preserves the acetylation state of acetyl-lysine modified proteins
sc-362323
2 ml
$55.00
1
KD 5170
An HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6 inhibitor
940943-37-3 sc-362755
10 mg
$185.00
0
TC-H 106
A class I HDAC (histone deacetylase) inhibitor
937039-45-7 sc-362801
sc-362801A
10 mg
50 mg
$155.00
$620.00
0
Tubacin
A selective inhibitor of HDAC6 that reversibly inhibits α-tubulin deacetylation
537049-40-4 sc-362815
sc-362815A
sc-362815B
sc-362815C
sc-362815D
1 mg
5 mg
50 mg
500 mg
1 g
$187.00
$415.00
$4,160.00
$10,330.00
$13,400.00
6
UNC 0224
A potent G9a histone lysine methyltransferase (HMTase) inhibitor
1197196-48-7 sc-362816
sc-362816A
10 mg
50 mg
$190.00
$800.00
0
4-iodo-SAHA
An HDAC1 and HDAC6 inhibitor
1219807-87-0 sc-364391
sc-364391A
50 mg
250 mg
$144.00
$650.00
0
C646
A selective p300, CBP, histone H3 and H4 inhibitor
328968-36-1 sc-364452
sc-364452A
10 mg
50 mg
$199.00
$902.00
0
Chidamide
An HDAC inhibitor
743420-02-2 sc-364462
sc-364462A
1 mg
5 mg
$60.00
$240.00
0
KW 2449
A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase
1000669-72-6 sc-364518
sc-364518A
10 mg
50 mg
$180.00
$744.00
0
PCI-34051
A potent and specific HDAC8 inhibitor
950762-95-5 sc-364566
sc-364566A
10 mg
100 mg
$175.00
$1,600.00
1
Pimelic Diphenylamide 106
An HDAC1, HDAC2, HDAC3, and HDAC8 inhibitor
937039-45-7 sc-364589
sc-364589A
1 mg
5 mg
$41.00
$74.00
0
Romidepsin
An HDAC1, HDAC2, HDAC4, and HDAC6 inhibitor
128517-07-7 sc-364603
sc-364603A
1 mg
5 mg
$568.00
$1,800.00
0
TAK-960
A Plk inhibitor
1137868-52-0 sc-364631
sc-364631A
5 mg
10 mg
$304.00
$640.00
0
Ac-Arg-Gly-Lys-MCA
sc-391017
sc-391017A
1 mg
5 mg
$45.00
$180.00
0
GSK J1
A selective and potent inhibitor of JMJDE and UTX demethylases
1373422-53-7 sc-391113
sc-391113A
10 mg
50 mg
$185.00
$781.00
0
GSK J4
A cell permeable inhibitor of the histone demethylase JMJD3/UTX
sc-391114
sc-391114A
10 mg
50 mg
$185.00
$781.00
0
I-BET 151 Hydrochloride
A BET bromodomain (BRD) inhibitor
1300031-49-5 (non HCl Salt) sc-391115
10 mg
$410.00
1
Demethoxy Curcumin
A demethoxy derivative of Curcumin
22608-11-3 sc-391590
10 mg
$188.00
0
1-Alaninechlamydocin
A cyclic tetrapeptide with potent antitumor activity
141446-96-0 sc-391717
500 µg
$200.00
0
Coumarin-SAHA
A fluorescent probe that competitively binds HDAC
1260635-77-5 sc-391815
sc-391815A
1 mg
10 mg
$56.00
$216.00
0
UNC 0646
A G9a and GLP, lysine methyltransferase inhibitor
1320288-17-2 sc-397060
10 mg
$185.00
0
GSK 525762A
1260907-17-2 sc-490339
sc-490339A
sc-490339B
sc-490339C
sc-490339D
5 mg
10 mg
50 mg
100 mg
1 g
$300.00
$500.00
$900.00
$1,680.00
$5,900.00
0

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