DNA Methylation

Santa Cruz Biotechnology now offers a broad range of DNA Methylation products. DNA Methylation products include compounds which can methylate DNA themselves or act as cofactors for enzyme-catalyzed methylation. Additionally, they include activators and inhibitors of DNA methyltransferases, such as Dnmt and MGMT. DNA methyltransferases help maintain genomic stability by repairing damage and helping prevent mismatch errors from occurring. Research has implicated several mutations affecting these enzymes in the growth and development of various cancers. Our popular products such as Streptozotocin (U-9889), Sinefungin, and S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt are typically available for immediate shipment.

indicates a highly recommended product based on customer preference.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Streptozotocin (U-9889)
An NO donor and DNA methylating agent
18883-66-4 sc-200719
sc-200719A
1 g
5 g
$104.00
$500.00
23
5-Aza-2prime-Deoxycytidine
A Dnmt inhibitor shown to alter gene expression
2353-33-5 sc-202424
25 mg
$200.00
1
Diethylamine NONOate
A quick-releasing NO donor and MGMT inhibitor
372965-00-9 sc-202575
sc-202575A
sc-202575B
10 mg
50 mg
100 mg
$31.00
$104.00
$190.00
0
O6-Benzylguanine
An effective substrate and efficient inactivator of DNA alkyltransferase
19916-73-5 sc-202747
sc-202747A
10 mg
50 mg
$44.00
$71.00
0
Mitoxantrone Dihydrochloride
Induces DNA damage by intercalating into DNA and inhibiting Topo II
70476-82-3 sc-203136
sc-203136A
10 mg
50 mg
$31.00
$57.00
3
Sinefungin
A SAM analog and Dnmt inhibitor
58944-73-3 sc-203263
sc-203263A
sc-203263B
sc-203263C
1 mg
10 mg
100 mg
1 g
$81.00
$499.00
$5,000.00
$38,800.00
3
Sodium bisulfite, mixture of NaHSO3 and Na2S2O5
An antioxidant and antimicrobial agent for DNA methylation studies
7631-90-5 sc-203273
sc-203273A
sc-203273B
sc-203273C
5 g
100 g
500 g
2.5 kg
$21.00
$23.00
$65.00
$163.00
0
Temozolomide
An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint
85622-93-1 sc-203292
sc-203292A
25 mg
100 mg
$80.00
$240.00
13
Zebularine
An inhibitor of DNA methyltransferase (Dnmt)
3690-10-6 sc-203315
sc-203315A
sc-203315B
10 mg
25 mg
100 mg
$119.00
$268.00
$960.00
2
RG 108
A Dnmt inhibitor that silences tumor suppressor genes
48208-26-0 sc-204235
sc-204235A
10 mg
50 mg
$125.00
$495.00
0
Chlorogenic Acid
A Bcr-Abl inhibitor
327-97-9 sc-204683
sc-204683A
500 mg
1 g
$40.00
$62.00
0
Disulfiram
An ALDH and tumor cell growth inhibitor
97-77-8 sc-205654
sc-205654A
50 g
100 g
$46.00
$80.00
1
Penicillin G procaine
A combination of Penicillin G and Procaine
6130-64-9 sc-205797
sc-205797A
10 g
25 g
$34.00
$36.00
0
1-Hydrazinophthalazine Hydrochloride
An inhibitor of Dnmt, MAO-A/B, and amine oxidase
304-20-1 sc-206167
10 g
$240.00
0
Temozolomide-d3
A labeled antineoplastic chemical
208107-14-6 sc-212996
1 mg
$220.00
0
N-Nitroso-N-ethylurea
A precursor of Diazoethane
759-73-9 sc-215469
sc-215469A
sc-215469B
sc-215469C
10 g
100 g
500 g
1 kg
$165.00
$1,600.00
$6,500.00
$9,500.00
0
R,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt
A methyl donor and cofactor for enzyme-catalyzed methylations
52248-03-0 sc-215827
sc-215827A
sc-215827B
25 mg
100 mg
500 mg
$61.00
$124.00
$600.00
0
3-Methyl-d3-adenine
An isotope labeled DNA methylater
5142-23-4 (unlabeled) sc-216512
1 mg
$200.00
0
5-Azacytidine-15N4
A Dnmt inhibitor
320-67-2 (unlabeled) sc-217140
1 mg
$450.00
0
5-Methylcytosine HCl
Useful in studying DNA methylation
58366-64-6 sc-217223
sc-217223A
250 mg
1 g
$101.00
$320.00
0
5-Azacytidine
A potent growth and Dnmt inhibitor
320-67-2 sc-221003
500 mg
$190.00
2
Procaine hydrochloride
A sodium channel blocker and DNA methylation inhibitor
51-05-8 sc-250776
250 mg
$61.00
0
Psammaplin A
A DNA methyltransferase inhibitor
110659-91-1 sc-258049
sc-258049A
1 mg
5 mg
$80.00
$400.00
3
Procaine
A sodium channel blocker and inhibitor of a variety of processes
59-46-1 sc-296134
sc-296134A
25 g
50 g
$101.00
$180.00
0
Lomeguatrib
A monosaccharide-linked inhibitor of MGMT
192441-08-0 sc-362764
sc-362764A
10 mg
50 mg
$205.00
$865.00
0
Semustine
An alkylating agent and interstrand DNA cross linker
13909-09-6 sc-391062
100 mg
$112.00
0
SGI-1027
An inhibitor of the DNA methyltransferases
1020149-73-8 sc-473875
10 mg
$165.00
0

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