Santa Cruz Biotechnology offers a variety of gene editing products to target cell adhesion proteins using the CRISPR/Cas9 system. Cell adhesion molecules (CAMs) influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. The four major families of cell adhesion molecules are immunoglobulin (Ig) superfamily (calcium-independent transmembrane glycoproteins), integrins (transmembrane non-covalently linked heterodimers of a and b subunits), calcium-dependent cadherins and divalent cation-dependent selectins. Mutation of CAM genes has been linked to several forms of cancer, effecting tumor growth and metastasis. Such important cell adhesion proteins include β-catenin, connexin, p120 and paxillin. To knockdown expression of cell adhesion proteins, Santa Cruz Biotechnology offers target-specific CRISPR/Cas9 Knockout (KO) Plasmids and CRISPR Double Nickase Plasmids.To activate transcription of cell adhesion protein genes, Santa Cruz Biotechnology offers target-specific CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems.
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