Crosslinkers

Santa Cruz Biotechnology now offers a broad range of Crosslinkers. Crosslinkers are used in the discovery of the molecular mechanisms of protein-protein interactions. Crosslinkers are either homo- or hetero-bifunctional reagents with identical or non-identical reactive groups, respectively, permitting the establishment of inter- as well as intra-molecular crosslinkages. View detailed Crosslinker specifications, including CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
4-Hydroxy-3-methoxybenzyl alcohol
CAS: 498-00-0, MF: C8H10O3, MW: 154.16, Purity: ≥98%
498-00-0 sc-254678
100 g
$109.00
0
3-(4-Hydroxymethylphenoxy)propionic acid
101366-61-4 sc-251913
1 g
$73.00
0
Methyltetrazine-NHS ester
sc-496797
25 mg
$225.00
0
Bis-propargyl-PEG6
sc-498229
250 mg
$390.00
0
1,4-Bis(diphenylphosphino)butane monooxide
85686-00-6 sc-224937
1 g
$87.00
0
Dimethyl pimelimidate dihydrochloride
A homobifunctional amine-reactive crosslinker
58537-94-3 sc-268943
sc-268943A
250 mg
1 g
$20.00
$35.00
0
Cy5-PEG4-acid
sc-499260
10 mg
$681.00
0
PEG NHS ester disulfide (n=7)
Commonly used as a linker molecule
947601-98-1 sc-236303
100 mg
$189.00
0
Bis-propargyl-PEG5
sc-498228
250 mg
$270.00
0
Sulfo-SMCC
A sulfhydryl- and amine-reactive crosslinker
92921-24-9 sc-212979
sc-212979A
sc-212979B
10 mg
100 mg
1 g
$72.00
$400.00
$1,800.00
0
Amino-PEG11-Amine
sc-496261
500 mg
$945.00
0
tert-Butyl 4-hydroxybutyrate
59854-12-5 sc-258207
500 mg
$267.00
0
Hydroxy-PEG-5-t-butyl ester
sc-499263
250 mg
$420.00
0
Biotin-PEG8-NHS ester
MF: C33H56N4O14S, MW: 764.88
sc-496460
100 mg
$645.00
0
Mal-PEG2-acid
sc-498178
100 mg
$480.00
0
Bis-propargyl-PEG2
sc-498225
100 mg
$360.00
0
Amino-PEG10-Amine
928292-69-7 sc-496260
250 mg
$480.00
0
PEG3-bis-(ethyl phosphonate)
sc-496501
100 mg
$390.00
0
m-PEG4-t-butyl ester
sc-498415
500 mg
$575.00
0
Fluorescein-PEG4-acid
sc-496182
50 mg
$480.00
0
Hydroxy-PEG6-t-butyl ester
sc-499264
250 mg
$390.00
0
1,4-Butanediyl diglycidyl ether
An epoxide monomer used for biochemical research
2425-79-8 sc-251594
10 g
$88.00
0
Biotinyl Cystamine
A crosslinking photoaffinity label ligand
128915-82-2 sc-210924
sc-210924A
10 mg
50 mg
$280.00
$890.00
0
N-Succinimidyl 6-[[4-(Maleimidomethyl)cyclohexyl]carboxamido] Caproate
125559-00-4 sc-219227
10 mg
$220.00
0
Biotin-PEG3-alcohol
sc-496454
100 mg
$525.00
0
Dimethyl suberimidate dihydrochloride
A homobifunctional imidoester based crosslinker, amine reactive
34490-86-3 sc-239782
5 g
$76.00
0
Bis-PEG7-acid
sc-496476
250 mg
$375.00
0
Tetrazine-Acid
sc-497779
25 mg
$225.00
0
m-PEG3-S-Acetyl
sc-498176
500 mg
$405.00
0
1,2-Bis(di-tert-butylphosphinomethyl)benzene
121954-50-5 sc-222791
sc-222791A
1 g
5 g
$157.00
$565.00
0
3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester
An amine- and sulfhydryl- reactive crosslinker, 4 atom spacer arm
68181-17-9 sc-209453
100 mg
$350.00
0
C18-PEG12-Amine
sc-498407
250 mg
$660.00
0
Diethylene glycol monoallyl ether
15075-50-0 sc-227853
5 ml
$544.00
0
DIDS, Disodium Salt
An anion transport inhibitor that inhibits Cl– uptake
67483-13-0 sc-203919
sc-203919A
sc-203919B
sc-203919C
250 mg
25 mg
100 mg
1 g
$170.00
$39.00
$120.00
$240.00
1
9-Hydroxy-9-(4-carboxyphenyl)xanthene
CAS: 191168-41-9, MF: C20H14O4, MW: 318.32
191168-41-9 sc-284863
sc-284863A
1 g
5 g
$150.00
$568.00
0
Methyltetrazine-PEG4-Maleimide
Maleimide (thiol reactive) functionalized methyl tetrazine for [4+2] inverse electron demand Diels-Alder click chemistry cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene; norbornene and cyclopropene to yield
1802908-02-6 sc-496794
4 mg
$285.00
0
Bromo-PEG4-bromide
sc-496289
250 mg
$270.00
0
Propargyl-PEG4-CH2CO2tBu
sc-498224
100 mg
$420.00
0
Azido-PEG2-Amine
sc-496111
100 mg
$225.00
0
(S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester
143106-46-1 sc-208358
10 mg
$250.00
0
3-(Maleimidopropane-1-carbonyl-1-(tert-butyl)carbazate
1076198-38-3 sc-357585
100 mg
$250.00
0
Amino-PEG9-Amine
sc-496259
500 mg
$796.00
0
Diethyl 4-aminoheptanedioate
sc-496505
100 mg
$345.00
0
Methoxytrityl-N-PEG12-acid
sc-496684
100 mg
$480.00
0
Biotin-PEG24-Acid
sc-496228
100 mg
$575.00
0
N-Dihydrocinnamoylaminocaproic Acid, N-Hydroxysuccinimide Ester
334616-48-7 sc-219147
10 mg
$220.00
0
N-[S-(2-Pyridylthioethyl)-t-Boc-aminooxyacetamide
sc-219003
10 mg
$220.00
0
TCO-PEG4-Acid
sc-498416
25 mg
$360.00
0
Bromo-PEG2-phosphonic acid
1446282-44-5 sc-496199
100 mg
$510.00
0
4,4'-Diisothiocyano-2,2'-dihydrostilbenedisulfonic Acid Disodium Salt
150321-88-3 sc-281687
250 mg
$250.00
0
Cy5-PEG3-Azide
sc-499262
2 mg
$345.00
0
1-Hydroxychlorodiene Hemisuccinate
sc-213338
2.5 mg
$300.00
0
Mal-PEG4-PFP
sc-498198
100 mg
$645.00
0
DBCO-mPEG 5KDa
sc-499443
25 mg
$225.00
0
Bromo-PEG4-t-butyl ester
sc-497002
250 mg
$420.00
0
Azido-PEG2-Azide
sc-496298
100 mg
$315.00
0
2-(t-Butoxycarbonylamido)-1,3-bis (carboxylethoxy)propane
sc-496509
100 mg
$420.00
0
Biotin-PEG4-alcohol
sc-496455
100 mg
$525.00
0
Amino-PEG24-alcohol
sc-496091
100 mg
$585.00
0
N-Hydroxysuccinimide
Useful in the carbodiimide method for improved amidations and peptide couplings
6066-82-6 sc-219162
100 g
$107.00
0
N-Z-1,6-hexanediamine hydrochloride
78618-06-1 sc-253133
1 g
$115.00
0
4-Maleimidobutyric Acid
A bifunctional crosslinking agent
57078-98-5 sc-210100
1 g
$250.00
0
Azido-PEG12-NHS ester
sc-496413
100 mg
$575.00
0
Thio-PEG4-t-butyl ester
sc-496477
100 mg
$330.00
0
m-PEG5-thiol
sc-498175
500 mg
$575.00
0
Bromo-PEG1-t-butyl ester
sc-496997
250 mg
$420.00
0
N-(5-Hydroxypentyl)trifluoroacetamide
128238-44-8 sc-253074
5 ml
$172.00
0
Acid-PEG24-NHS ester
sc-496135
100 mg
$681.00
0
Amino-PEG5-alcohol
sc-496088
100 mg
$240.00
0
Octaoxahexacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester
sc-219459
5 mg
$350.00
0
Azido-PEG1- t-butyl ester
sc-496267
100 mg
$345.00
0
C18-PEG4-Amine
sc-498406
500 mg
$525.00
0
N-Z-1,4-Butanediamine hydrochloride
18807-73-3 sc-253131
1 g
$142.00
0
Bromo-PEG1-CH2CO2tBu
sc-497009
100 mg
$480.00
0
Propargyl-PEG5-amine
sc-498241
250 mg
$585.00
0
3-(Boc-amino)propyl bromide
A versatile building block
83948-53-2 sc-231352
500 mg
$93.00
0
(4-Hydroxyphenyl)diphenylphosphine
5068-21-3 sc-232774
1 g
$321.00
0
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic Acid
A bifunctional iron chelating agent
1217704-71-6 sc-220047
5 mg
$280.00
0
N-Z-Ethylenediamine hydrochloride
18807-71-1 sc-250493
sc-250493A
250 mg
1 g
$32.00
$56.00
0
6-(N-Trifluoroacetyl)caproic acid NHS
Used to temporarily block amine groups in target molecules and to extend lysine side chains to reduce steric hindrance
sc-478829
250 mg
$284.00
0
Biotin-PEG4-PFP ester
sc-496464
100 mg
$540.00
0
Lipoamide-PEG11-Mal
sc-496849
100 mg
$728.00
0
Tos-PEG3-CH2CO2tBu
sc-496270
250 mg
$540.00
0
Methyltetrazine-PEG4-Azide
sc-496793
10 mg
$225.00
0
Bis-propargyl-PEG3
sc-498226
250 mg
$345.00
0
Amino-PEG3-alcohol
sc-496070
1 g
$203.00
0
SPDP-PEG6-acid
sc-496496
100 mg
$575.00
0
PEG3-bis(phosphonic acid)
sc-496500
100 mg
$480.00
0
Amino-PEG5-CH2CO2H
141282-35-1 sc-496682
250 mg
$540.00
0
1,8-Diazido-3,6-dioxaoctane
A multifunctional alkylating agent
59559-06-7 sc-208814
1 g
$533.00
0
Tos-PEG5 t-butyl ester
sc-496227
1 g
$525.00
0
(S,S)-1,2-Bis[(tert-butyl)methylphosphino]ethane Bis(borane)
CAS: 203000-48-0, MF: C12H34B2P2, MW: 261.97
203000-48-0 sc-296298
100 mg
$253.00
0
(R)-Binaphane
A chiral catalysis
253311-88-5 sc-255515
sc-255515A
sc-255515B
100 mg
250 mg
50 mg
$200.00
$500.00
$175.00
0
3-(Fmoc-amino)propyl bromide
186663-83-2 sc-231374
5 g
$328.00
0
Azido-PEG5-NHS ester
sc-496410
100 mg
$420.00
0
Amino-PEG24-acid
sc-496190
100 mg
$575.00
0
1,14-Diazido-3,6,9,12-tetraoxatetradecane
182760-73-2 sc-206217
250 mg
$300.00
0
m-PEG12-acid
sc-498414
100 mg
$443.00
0
Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid
sc-496205
100 mg
$525.00
0
Azido-PEG6-PFP ester
sc-496422
100 mg
$420.00
0
1,2-Bis(2-iodoethoxy)ethane
A crosslinking reagent
36839-55-1 sc-222786
5 g
$30.00
0
Cy5-PEG6-acid
sc-499261
5 mg
$480.00
0
tetraethyl octane-1,8-diylbis(phosphonate)
sc-496874
250 mg
$390.00
0
4'-Hydroxy-2,4-dimethoxybenzophenone
A linker employed for solid-phase peptide synthesis
41351-30-8 sc-252231
5 g
$49.00
0
3-(2-bromoacetamido)propanoic acid NHS ester
sc-496293
100 mg
$270.00
0
Azido-PEG1-Azide
CAS: 24345-74-2, MF: C4H8N6O, MW: 156.15
24345-74-2 sc-496299
100 mg
$315.00
0
2,3,4,6-tetra-o-acetyl-alpha-galactosylpyranosyl bromide
sc-496866
1 g
$360.00
0
Fmoc-Photo-Linker
CAS: 162827-98-7, MF: C28H28N2O8, MW: 520.56
162827-98-7 sc-294977
sc-294977A
100 mg
1 g
$250.00
$600.00
0
Thiol-PEG4-Alcohol
sc-496824
100 mg
$420.00
0
Biotin-PEG4-TFP ester
sc-496465
100 mg
$420.00
0
Amino-PEG5-t-butyl ester
sc-496251
100 mg
$360.00
0
Amino-PEG12-alcohol
sc-496090
100 mg
$525.00
0
3-(2-Pyridylthio)propanoic Acid
A crosslinking agent in the immobilization of thrombogenesis-inhibiting enzymes
68617-64-1 sc-206596
50 mg
$220.00
0
N-Boc-2-isothiocyanatoethylamine
137743-46-5 sc-250448
500 mg
$145.00
0
Azido-PEG1-PFP ester
sc-496414
100 mg
$390.00
0
3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
A cleavable disulfide linkage-containing homobifunctional cross-linking reagent
57757-57-0 sc-266859
500 mg
$140.00
0
Glutaraldehyde solution, 25% w/w
A protein cross-linking agent
111-30-8 sc-300764
sc-300764A
100 ml
10 ml
$32.00
$20.00
0
4-Nitrophenyl chloroformate
A zero length crosslinker
7693-46-1 sc-254713
sc-254713A
5 g
25 g
$34.00
$95.00
0
Chloroacetamido-PEG4- NHS ester
sc-497030
100 mg
$330.00
0
Azido-PEG6- t-butyl ester
sc-496364
100 mg
$330.00
0
Glyoxal, 40 % Solution
Used to denature nucleic acids by forming stable complexes with guanine residues
107-22-2 sc-285868
sc-285868A
25 ml
50 ml
$48.00
$74.00
0
1,8-Bis-maleimidotetraethyleneglycol
A homobifunctional sulfhydryl-reactive crosslinker
115597-84-7 sc-208810
25 mg
$220.00
0
10-bromodecylphosphonic acid
sc-497769
100 mg
$420.00
0
Bis-PEG2-PFP ester
sc-496483
250 mg
$345.00
0
5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester
A nitrate-containing, aryl azide-based, amine- and photoreactive crosslinker
60117-35-3 sc-256884
100 mg
$222.00
0
3-[(2-Aminoethyl)dithio]propionic Acid
A useful reversible immobilization or crossliking reagent
15579-00-7 sc-209496
100 mg
$220.00
0
Erbstatin Analog
A stable inhibitor of EGFR tyrosine kinase
63177-57-1 sc-200511
sc-200511A
5 mg
25 mg
$81.00
$299.00
4
Bromo-PEG5-alcohol
sc-496994
250 mg
$375.00
0
di-Boc-cystamine
A building block used in the synthesis of thioethyl-modified peptides
67385-10-8 sc-252671
5 g
$127.00
0
Suberic acid bis(N-hydroxysuccinimide ester)
A homobifunctional amine-reactive crosslinker, 8 atom spacer arm
68528-80-3 sc-253611
sc-253611A
500 mg
1 g
$72.00
$119.00
0
Mal-PEG8-acid
sc-498190
100 mg
$480.00
0
Bis-(2-methanethiosulfonatoethyl)dimethylammonium Chloride
sc-217766
5 mg
$280.00
0
HBTU
A coupling reagent often used in solid phase peptide synthesis
94790-37-1 sc-203074
sc-203074A
100 g
250 g
$289.00
$578.00
0
1,2-Bis[bis(pentafluorophenyl)phosphino]ethane
76858-94-1 sc-222810
1 g
$75.00
0
Hydroxy-PEG5-CH2CO2tBu
sc-496960
250 mg
$525.00
0
Acid-PEG13-NHS ester
sc-496134
100 mg
$540.00
0
DBCO-PEG5-NHS ester
sc-499348
10 mg
$225.00
0
Azido-PEG2- t-butyl ester
sc-496268
100 mg
$225.00
0
C18-PEG7-Acid
sc-498409
250 mg
$450.00
0
Biotin-LC-Hydrazide
sc-496469
100 mg
$345.00
0
3-(Benzophenone-4-carboxamido)-2-maleimidopropanoic acid
A maleimide derivative
887352-68-3 sc-209472
5 mg
$280.00
0
N1,N1'-(1,4-phenylenebis(methylene))bis(N1-(2-aminoethyl)ethane-1,2-diamine)
sc-496870
50 mg
$525.00
0
N-Z-1,5-pentanediamine hydrochloride
18807-74-4 sc-253132
500 mg
$106.00
0
Bis-PEG17-acid
sc-496957
100 mg
$575.00
0
6-[2-Biotinylamidoethyl]-dithiopropionamido]-4,8-diaza-5,7-diketoundecanoic Acid, Bis-N-sulfosuccinimidyl Ester Disodium Salt
A cleavable Suflo-NHS and biotin containing crosslinker
1044220-56-5 sc-207084
1 mg
$250.00
0
Trans-3,4-Bis(methylmethanethiosulfonylmethyl)-2,2,5,5-tetramethylpyrrolidin-1-yloxyl Radical
A cross-linking, sulfhydryl spin label
229621-30-1 sc-213085
1 mg
$263.00
0
Tos-PEG5-CH2CO2t-butyl ester
sc-496232
250 mg
$540.00
0
Benzyl-PEG2-Azide
sc-496438
250 mg
$575.00
0