Z-FA-FMK CAS: 197855-65-5
MF: C21H23FN2O4
MW: 386.42
Inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis.

Z-FA-FMK (CAS 197855-65-5)

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Nomes alternativos: Z-Phe-Ala fluoromethyl ketone
Aplicação Z-FA-FMK is inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis
Numero VAT: 197855-65-5
Privada: ≥95%
Peso Molecular: 386.42
Separar por Funcao: C21H23FN2O4
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Z-FA-FMK is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S, that do not require a P1 Asp residue. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3, caspase-6, and caspase-7 without affecting initiator caspase-8 and caspase-10 while showing minimal toxicity to normal mammalian cells in vitro. Due to Z-FA-FMK's effector caspase specificity, the compound has been recorded to inhibit some forms of caspase mediated apoptosis. The compound has been observed to be an effective in time dependent inactivation of cathepsin B isozymes from a number of tissues. Studies show Cathepsin B-like activity plays a role in the cascade of proteolytic cartilage destruction. Z-FA-FMK is an inhibitor of cathepsin H.


Referencias

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Estado físico :
Solid
envie :
Soluble in DMSO (10 mM).
Manutencao :
Store at -20° C
Ponto de fusão :
~226.14° C (Predicted)
Ponto de fervura :
630.54° C at 760 mmHg
Densidade :
1.21 g/cm3
Indice de produtos :
n20D 1.55
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00883668
SMILES :
CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

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Z-FA-FMK (CAS 197855-65-5)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Z-FA-FMK (CAS 197855-65-5). Clique em PubMed para ver .

Citações 1 para 10 de 15 total

PMID: # 30720418  Fuller, J.|Surtees, RA.|Shaw, AB.|Álvarez-Rodríguez, B.|Slack, GS.|Bell-Sakyi, L.|Mankouri, J.|Edwards, TA.|Hewson, R.|Barr, JN.| et al. 2019. J Gen Virol. 100: 392-402.

PMID: # 26639105  Staines, KA. et al. 2016. J. Cell. Physiol. 231: 1392-404.

PMID: # 27084336  Zhou, Y. et al. 2016. Mol Neurodegener. 11: 28.

PMID: # 28105029  Welsby, I. et al. 2016. Front Immunol. 7: 663.

PMID: # 25092290  Singh, D. et al. 2014. The Journal of biological chemistry. 289: 27614-24.

PMID: # 24085292  Lee, KH. et al. 2013. J. Biol. Chem. 288: 32777-86.

PMID: # 23812099  Sheedy, FJ.|Grebe, A.|Rayner, KJ.|Kalantari, P.|Ramkhelawon, B.|Carpenter, SB.|Becker, CE.|Ediriweera, HN.|Mullick, AE.|Golenbock, DT.|Stuart, LM.|Latz, E.|Fitzgerald, KA.|Moore, KJ.| et al. 2013. Nat Immunol. 14: 812-20.

PMID: # 22865861  Qi, R. et al. 2012. J. Biol. Chem. 287: 32617-29.

PMID: # 18255115  Gorria, M. et al. 2008. Toxicol. Appl. Pharmacol. 228: 212-224.

PMID: # 18567942  Wen, YD.|Sheng, R.|Zhang, LS.|Han, R.|Zhang, X.|Zhang, XD.|Han, F.|Fukunaga, K.|Qin, ZH.| et al. 2008. Autophagy. 4: 762-9.

Citações 1 para 10 de 15 total
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