Sorry, it seems JavaScript is not enabled in your browser. Please enable it to get the best site experience.

Vincristine Sulfate | CAS 2068-78-2 | SCBT - Santa Cruz Biotechnology
Vincristine Sulfate CAS: 2068-78-2
Vincristine Sulfate is a cell cycle arresting, apoptotic inducing alkaloid.

Vincristine Sulfate (CAS 2068-78-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 104ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Vincristine Sulfate is rated 5.0 out of 5 by 2.
Nomes alternativos: VCR . sulfate;Leukocristine . sulfate
Aplicação Vincristine Sulfate is a cell cycle arresting, apoptotic inducing alkaloid
Numero VAT: 2068-78-2
Privada: ≥98%
Peso Molecular: 923.04
Separar por Funcao: C46H56N4O10•H2SO4
Informação complementar: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
Faça a sua avaliação desse produto e receba 15 CruzCredits

Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.


  1. The morphological effects of vincristine sulfate on canine bone marrow cells.  |  Alleman, AR. and Harvey, JW. 1993. Vet Clin Pathol. 22: 36-41. PMID: 12669276
  2. Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins.  |  Li, Y., et al. 1992. Biochem Biophys Res Commun. 187: 722-9. PMID: 1530630
  3. Vincristine sulfate as a possible cause of optic neuropathy.  |  Weisfeld-Adams, JD., et al. 2007. Pediatr Blood Cancer. 48: 238-40. PMID: 16206187
  4. Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules.  |  Himes, RH. 1991. Pharmacol Ther. 51: 257-67. PMID: 1784631
  5. PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency.  |  Song, X., et al. 2008. Int J Pharm. 350: 320-9. PMID: 17913411
  6. Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition.  |  Ling, G., et al. 2010. J Control Release. 148: 241-8. PMID: 20727928
  7. Folic acid and cell-penetrating peptide conjugated PLGA-PEG bifunctional nanoparticles for vincristine sulfate delivery.  |  Chen, J., et al. 2012. Eur J Pharm Sci. 47: 430-43. PMID: 22796217
  8. Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine.  |  Silverman, JA. and Deitcher, SR. 2013. Cancer Chemother Pharmacol. 71: 555-64. PMID: 23212117
  9. Multifunctional nanoparticles as nanocarrier for vincristine sulfate delivery to overcome tumor multidrug resistance.  |  Wang, Y., et al. 2014. Mol Pharm. 11: 885-94. PMID: 24483832
  10. Clinical pharmacokinetics and effects of vincristine sulfate in dogs with transmissible venereal tumor (TVT).  |  Hantrakul, S., et al. 2014. J Vet Med Sci. 76: 1549-53. PMID: 25649934
  11. Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.  |  Setthawongsin, C., et al. 2019. Front Vet Sci. 6: 300. PMID: 31620453
  12. Pharmacokinetics of vincristine sulfate in adult cancer patients.  |  Sethi, VS., et al. 1981. Cancer Res. 41: 3551-5. PMID: 7260915
  13. Pharmacokinetics of vincristine sulfate in children.  |  Sethi, VS. and Kimball, JC. 1981. Cancer Chemother Pharmacol. 6: 111-5. PMID: 7307229
  14. Bcl-2 interrupts the ceramide-mediated pathway of cell death.  |  Zhang, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 5325-8. PMID: 8643573
  15. Pharmacokinetic behavior of vincristine sulfate following administration of vincristine sulfate liposome injection.  |  Embree, L., et al. 1998. Cancer Chemother Pharmacol. 41: 347-52. PMID: 9523729

Aparência :
Estado físico :
envie :
Soluble in water (25 mg/ml), ethanol, and methanol.
Manutencao :
Store at -20° C
Ponto de fusão :
300° C
Ponto de fervura :
273-281° C
IC50 :
OVCAR-3 : IC50 = 10 nM (human); PC-3: IC50 = 11 nM (human); LNCaP: IC50 = 2.9 nM (human)
Valores de pK :
pKa: 11.10
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
PubChem CID :
Indice de produtos :
14: 9986
Numero de FAX :
Numero de FAX :
Registro Beilstein :
CC[[email protected]@]1(C[[email protected]]2C[[email protected]@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[[email protected]]78CCN9[[email protected]]7[[email protected]@](C=CC9)([[email protected]]([[email protected]@]([[email protected]@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

Baixar SDS (MSDS)

Certificado de Análise

SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-201434
Lot Number:SAMPLE
Product Name:Vincristine Sulfate
Molecular Formula:C46H56N4O10•H2SO4
Molecular Weight:923.0
AppearanceWhite to off-white solidWhite solid
MicroanalysisElemental analysis within 0.4 of expected result for each element testedComplies
Identification (1H-NMR)Consistent with structure and shows < 1% of any other impurityComplies
Identification (Mass Spectrometry)Electrospray positive shows mass ion corresponding to [M-H2SO4+H]+ and [M-H2SO4+2H]2+Mass ions: 825.5 and 413.5
Purity (HPLC)> 98% by RP analysisComplies
TLCSingle spotRf = 0.50
SolubilitySoluble in water to 100 mMComplies


NMR Conditions: 300 MHz in D2OTLC Conditions: PAW: BuOH = 2: 3; Visualized by UV and Ninhydrin

Vincristine Sulfate (CAS 2068-78-2)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Vincristine Sulfate (CAS 2068-78-2). Clique em PubMed para ver .

Citações 1 para 10 de 14 total

PMID: 24667756 | Study of the stability of 26 cytostatic drugs and metabolites in wastewater under different conditions. | Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: 24248406 | Lectin levels in tissues of cultured immature wheat embryos | Negreira, N. et al. 2013. Talanta. 116: 290-9.

Citações 1 para 10 de 14 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 99ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;