V-ATPase B2 Anticorpo D-11é um anticorpo monoclonal produzido em camundongo IgG2a κ, citado em 2 publicações, fornecido em 200 µg/ml
específico para um epítopo mapeado entre os aminoácidos2-38 no N-terminus de V-ATPase B2 de human origem
Anti-V-ATPase B2 Anticorpo (D-11) é recomendado para a detecção de V-ATPase B2 de mouse, rat e human origem em WB, IP, IF, IHC(P) e ELISA; Reage também com outras espécies, incluindo and canine and bovine
Anti-V-ATPase B2 Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de V-ATPase B2 (D-11): sc-166045.
m-IgGκ BP-HRP is the preferred secondary detection reagent for V-ATPase B2 Antibody (D-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with V-ATPase B2 Antibody (D-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
ChemCruz™ Produtos químicos
V-ATPase Inibidores para análise funcional de respostas celulares a V-ATPase
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Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c′ and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts. The gene encoding the human V-ATPase B2 isoform maps to chromosome 8p22-p21.
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