Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-6 cells with an IC50 value of 35 µM.1
1 Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994). 2 Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic & Clinical Pharmacology & Toxicology 98 44-50 (2006).
Soluble in DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:2 solution of DMSO:PBS (pH 7.2) (~0.3 mg/ml).
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