Anti-TLE3 Anticorpo D-10é um anticorpo monoclonal produzido em camundongo IgG1 κ TLE3 anticorpo, citado em 1 publicações, fornecido em 200 µg/ml
Produzido contra aminoácidos 200-400 de TLE3 de mouse origem
Anti-TLE3 Anticorpo (D-10) é recomendado para a detecção de TLE3 de mouse, rat e human origem em WB, IP, IF, IHC(P) e ELISA
Anti-TLE3 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
disponível como reagente TransCruz para ensaios de Gel Supershift e uso em ChIP (sc-514798 X, 200 µg/0.1 ml)
Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de TLE3 (D-10): sc-514798.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TLE3 Antibody (D-10) for WB and IHC(P) applications. These reagents are now offered in bundles with TLE3 Antibody (D-10) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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TLE3 Antibody (D-10) is a high quality monoclonal TLE3 antibody (also designated Enhancer of split groucho-like protein 3 (ESG3) antibody) suitable for the detection of the TLE3 protein of mouse, rat and human origin. TLE3 Antibody (D-10) is available as both the non-conjugated anti-TLE3 antibody form, as well as multiple conjugated forms of anti-TLE3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences