Tiamulin is an analog of pleuromutilin (sc-202293) which demonstrates greater hydrophobicity due to the diethylaminoethylthioacetyl group and is more easily ionized to increase water solubility. Tiamulin is a gram-positive antibiotic that works by inhibiting protein synthesis through the binding of domain V of the 23S rRNA.
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PMID: # 31035614 Kubohara, Y.|Shiratsuchi, Y.|Ishigaki, H.|Takahashi, K.|Oshima, Y.|Kikuchi, H.| et al. 2019. Biomolecules. 9: